Differential expression of distinct microtubule-associated proteins during brain development.

Détails

ID Serval
serval:BIB_9BE5D6D04F99
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Differential expression of distinct microtubule-associated proteins during brain development.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Riederer B., Matus A.
ISSN
0027-8424 (Print)
ISSN-L
0027-8424
Statut éditorial
Publié
Date de publication
1985
Volume
82
Numéro
17
Pages
6006-6009
Langue
anglais
Résumé
The levels of three different microtubule-associated proteins (MAP1, -2, and -3) in brain were found to undergo large changes during postnatal development. MAP1 was barely detectable at birth but thereafter steadily increased, reaching adult levels by postnatal day 20 (P20). Both MAP2 and MAP3 showed differential expression patterns of their component peptides. At birth, MAP2 was represented by the smaller of two Mr 280,000 peptides (MAP2b) and three antigenically related Mr 70,000 peptides. The larger of the Mr 280,000 peptides (MAP2a) first appeared between P10 and P20, and the Mr 70,000 components disappeared at the same time. Of the two MAP3 peptides, the larger (MAP3a) was present in the late embryo, several days before MAP3b appeared. Between P10 and P20, both MAP3 components underwent a striking decrease in abundance (a factor of 10), which correlated with their disappearance from all neuronal compartments except neurofilament-containing axons. These developmental changes in expression are different and characteristic for each of the three MAPs, yet in each case they are detectable in brain homogenates, indicating that they occur concurrently throughout the brain.
Mots-clé
Animals, Animals, Newborn/metabolism, Antibodies, Monoclonal/diagnostic use, Brain/growth & development, Brain/metabolism, Cerebellum/growth & development, Cerebellum/metabolism, Cerebral Cortex/growth & development, Cerebral Cortex/metabolism, Immunoenzyme Techniques, Microtubule-Associated Proteins/metabolism, Molecular Weight, Nerve Tissue Proteins/metabolism, Rats
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 15:34
Dernière modification de la notice
20/08/2019 16:02
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