Association of endogenous sex hormones with diabetes and impaired fasting glucose in men: multi-ethnic study of atherosclerosis.

Détails

ID Serval
serval:BIB_9BAEA12F37E3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Association of endogenous sex hormones with diabetes and impaired fasting glucose in men: multi-ethnic study of atherosclerosis.
Périodique
Diabetes care
Auteur⸱e⸱s
Colangelo L.A., Ouyang P., Liu K., Kopp P., Golden S.H., Dobs A.S., Szklo M., Vaidya D., Cushman M., Gapstur S.M.
ISSN
1935-5548 (Electronic)
ISSN-L
0149-5992
Statut éditorial
Publié
Date de publication
06/2009
Peer-reviewed
Oui
Volume
32
Numéro
6
Pages
1049-1051
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Résumé
To assess associations of sex hormones with impaired fasting glucose (IFG) and type 2 diabetes in men.
A total of 3,156 African American, Non-Hispanic white, Hispanic, and Chinese-American men aged 45-84 years who participated in the baseline visit of the Multi-Ethnic Study of Atherosclerosis (MESA) were included. Odd sratios and 95% CIs for type 2 diabetes and IFG compared with normal fasting glucose for quartiles of hormones were estimated.
After adjusting for age, ethnicity, BMI, and waist circumference, IFG and diabetes were associated inversely with total testosterone and sex hormone-binding globulin (SHBG) and positively with estradiol (E2). Dehydroepiandrosterone was positively associated with IFG but not with diabetes. Associations did not differ across ethnic groups.
Regardless of obesity, total testosterone and SHBG were associated inversely and E2 was associated positively with IFG and diabetes in men. Further research is warranted to better understand the underlying biological mechanisms.
Mots-clé
Aged, Aged, 80 and over, Atherosclerosis/epidemiology, Body Mass Index, Cohort Studies, Continental Population Groups, Dehydroepiandrosterone/blood, Diabetes Complications/blood, Diabetes Complications/epidemiology, Diabetes Mellitus/blood, Estradiol/blood, Ethnic Groups, Glucose Intolerance/blood, Glucose Intolerance/complications, Humans, Male, Middle Aged, Sex Hormone-Binding Globulin/metabolism, Testosterone/blood, Waist Circumference
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/12/2020 14:00
Dernière modification de la notice
31/12/2020 6:26
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