The targeted delivery of cancer drugs across the blood-brain barrier: chemical modifications of drugs or drug-nanoparticles?

Détails

ID Serval
serval:BIB_9BA627F04E4D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The targeted delivery of cancer drugs across the blood-brain barrier: chemical modifications of drugs or drug-nanoparticles?
Périodique
Drug Discovery Today
Auteur⸱e⸱s
Juillerat-Jeanneret L.
ISSN
1359-6446
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
13
Numéro
23-24
Pages
1099-1106
Langue
anglais
Notes
Publication types: Journal Article ; Review -
Résumé
One of the most challenging problems, if not the most challenging, in drug development is not to develop drugs to treat diseases of the central nervous system (CNS), but to manage to distribute them to the CNS across the blood-brain barrier (BBB) using transvascular routes following intravenous administration. The development of BBB targeting technologies is a very active field of research and development. One goal is to develop chemically modified derivatives of drugs or chemically modified nanoparticulate vectors of drugs, capable of crossing biological barriers, in particular the BBB. This manuscript will review the approaches that have been explored to achieve these goals, using chemical functionalization of drugs or of drug vector systems and endogenous transporters at the BBB.
Mots-clé
Antineoplastic Agents, Biological Transport, Blood-Brain Barrier, Brain Neoplasms, Drug Carriers, Drug Delivery Systems, Drug Design, Humans, Nanoparticles
Pubmed
Web of science
Création de la notice
16/12/2008 11:17
Dernière modification de la notice
20/08/2019 16:02
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