Disseminated Rhizopus microsporus infection cured by salvage allogeneic hematopoietic stem cell transplantation, antifungal combination therapy, and surgical resection.

Détails

ID Serval
serval:BIB_9B72D655480E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Disseminated Rhizopus microsporus infection cured by salvage allogeneic hematopoietic stem cell transplantation, antifungal combination therapy, and surgical resection.
Périodique
Transplant infectious disease
Auteur(s)
Lebeau O., Van Delden C., Garbino J., Robert J., Lamoth F., Passweg J., Chalandon Y.
ISSN
1399-3062 (Electronic)
ISSN-L
1398-2273
Statut éditorial
Publié
Date de publication
06/2010
Peer-reviewed
Oui
Volume
12
Numéro
3
Pages
269-272
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
Invasive Zygomycetes infection complicating prolonged neutropenia is associated with high mortality in the absence of immune recovery. We report a patient who developed disseminated zygomycosis due to Rhizopus microsporus during induction chemotherapy for acute myeloid leukemia. Rescue allogeneic hematopoietic stem cell transplantation (allo-HSCT) was performed as her only chance of cure of this infection and to treat refractory leukemia. Posaconazole combined with liposomal amphotericin B contained the zygomycosis during prolonged neutropenia due to allo-HSCT followed by intense immunosuppression for grade IV acute graft-versus-host disease. Surgical removal of all infected sites after immune recovery, with prolonged posaconazole treatment, ultimately cured the infection. New combination antifungal therapies might sufficiently control disseminated zygomycosis to allow allo-HSCT to be performed, assuring life-saving immune recovery. Surgery appears to be necessary for definite cure of these infections.
Mots-clé
Amphotericin B/therapeutic use, Antifungal Agents/therapeutic use, Drug Therapy, Combination, Female, Hematopoietic Stem Cell Transplantation, Humans, Leukemia, Myeloid, Acute/complications, Leukemia, Myeloid, Acute/drug therapy, Middle Aged, Mucormycosis/drug therapy, Mucormycosis/immunology, Mucormycosis/microbiology, Mucormycosis/surgery, Rhizopus/classification, Rhizopus/drug effects, Rhizopus/isolation & purification, Salvage Therapy, Transplantation, Homologous, Treatment Outcome, Triazoles/therapeutic use
Pubmed
Web of science
Création de la notice
04/10/2019 6:58
Dernière modification de la notice
05/10/2019 5:26
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