Impairment of the myocardial vasomotor response to cold pressor stress in collateral dependent myocardium

Détails

ID Serval
serval:BIB_9B529FA70EA1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Impairment of the myocardial vasomotor response to cold pressor stress in collateral dependent myocardium
Périodique
Heart
Auteur⸱e⸱s
Uren  N. G., Crake  T., Tousoulis  D., Seydoux  C., Davies  G. J., Maseri  A.
ISSN
1355-6037 (Print)
Statut éditorial
Publié
Date de publication
07/1997
Volume
78
Numéro
1
Pages
61-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Résumé
OBJECTIVE: To study the vasomotor response (cold pressor/basal flow) in myocardium perfused entirely by collaterals, using the reflex sympathetic stimulation of cold pressor stress. DESIGN: Regional myocardial blood flow was measured in collateral dependent and in remote myocardium using positron emission tomography with 15O water at basal and at cold pressor stress. Regional ischaemia was measured with 18F-fluorodeoxyglucose (FDG). PATIENTS: Nine patients (mean (SD) age 53 (6) years) with an occluded coronary artery supplied entirely by collaterals from other angiographically normal arteries. RESULTS: In remote myocardium, basal and cold pressor flow were 0.99 (0.26) and 1.46 (0.60) ml/min/g (P < 0.05), respectively, a myocardial vasomotor response of 1.46 (0.45). In collateral dependent myocardium, basal and cold pressor flow were 0.91 (0.20) and 0.87 (0.35) ml/min/g, respectively (the latter value, P < 0.05 v remote region), a myocardial vasomotor response of 0.97 (0.43) (P < 0.05 v remote region). The myocardial vascular resistance (mean arterial pressure/flow) during cold pressor was higher in the collateral dependent than in remote myocardium, at 147.0 (61.1) and 85.6 (32.3) mm Hg.min.g/ml (P < 0.05), respectively, but with no relative increase in FDG uptake. CONCLUSIONS: In contrast to the decrease in myocardial resistance in remote myocardium with cold pressor, an increase was observed in collateral dependent myocardium suggesting a vasoconstrictor response in resistive vessels, without demonstrable myocardial ischaemia.
Mots-clé
Cold/diagnostic use *Collateral Circulation Coronary Disease/*physiopathology/radionuclide imaging Female Heart/*physiopathology/radionuclide imaging Humans Male Middle Aged Reflex Stress Tomography, Emission-Computed Vascular Resistance/physiology Vasoconstriction/physiology Vasomotor System/*physiopathology
Pubmed
Web of science
Création de la notice
28/01/2008 10:11
Dernière modification de la notice
20/08/2019 15:02
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