Hyperpolarized (6)Li as a probe for hemoglobin oxygenation level.

Détails

Ressource 1Télécharger: BIB_9B43C1B2921F.P001.pdf (704.60 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_9B43C1B2921F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Hyperpolarized (6)Li as a probe for hemoglobin oxygenation level.
Périodique
Contrast media & molecular imaging
Auteur⸱e⸱s
Balzan R., Mishkovsky M., Simonenko Y., van Heeswijk R.B., Gruetter R., Eliav U., Navon G., Comment A.
ISSN
1555-4317 (Electronic)
ISSN-L
1555-4309
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
11
Numéro
1
Pages
41-46
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Hyperpolarization by dissolution dynamic nuclear polarization (DNP) is a versatile technique to dramatically enhance the nuclear magnetic resonance (NMR) signal intensity of insensitive long-T1 nuclear spins such as (6)Li. The (6)Li longitudinal relaxation of lithium ions in aqueous solutions strongly depends on the concentration of paramagnetic species, even if they are present in minute amounts. We herein demonstrate that blood oxygenation can be readily detected by taking advantage of the (6)Li signal enhancement provided by dissolution DNP, together with the more than 10% decrease in (6)Li longitudinal relaxation as a consequence of the presence of paramagnetic deoxyhemoglobin.

Mots-clé
Animals, Contrast Media/chemistry, Contrast Media/pharmacology, Hemoglobins/chemistry, Hemoglobins/metabolism, Humans, Ions/chemistry, Lithium/chemistry, Lithium/pharmacology, Magnetic Resonance Imaging/methods, Magnetic Resonance Spectroscopy, Rats
Pubmed
Création de la notice
17/02/2016 14:24
Dernière modification de la notice
20/08/2019 15:02
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