Predictors of poor response to methotrexate in polyarticular-course juvenile idiopathic arthritis: analysis of the PRINTO methotrexate trial.

Détails

ID Serval
serval:BIB_9AF3A57274C8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Predictors of poor response to methotrexate in polyarticular-course juvenile idiopathic arthritis: analysis of the PRINTO methotrexate trial.
Périodique
Annals of the Rheumatic Diseases
Auteur(s)
Vilca I., Munitis P.G., Pistorio A., Ravelli A., Buoncompagni A., Bica B., Campos L., Häfner R., Hofer M., Ozen S., Huemer C., Bae S.C., Sztajnbok F., Arguedas O., Foeldvari I., Huppertz H.I., Gamir M.L., Magnusson B., Dressler F., Uziel Y., van Rossum M.A., Hollingworth P., Cawkwell G., Martini A., Ruperto N.
Collaborateur(s)
Pediatric Rheumatology International Trials Organisation (PRINTO)
Contributeur(s)
Murray KJ., Joos R., Wouters C., Oliveira S., Magalhães CS., Ferriani V., Mihaylova D., Dolezalova P., Lahdenne P., Minden K., Brik R., Gerloni V., Alessio M., Corona F., Falcini F., Zulian F., Alpigiani MG., Cortis E., Lepore L., Galasso R., Burgos-Vargas R., Wulffraat N., ten Cate R., van Soesberger R., Asplin L., Flato B., Rygg M., Vesely R., Garcia-Consuegra J., Merino R., Calvo I., Andersson-Gare B., Saurenmann R., Sauvain MJ., Bakkaloglu A., Ozdogan H., Baildam E., Davidson J., Foster H., Walsh J., Hall A., Venning H., Woo P., Hashkes P., Kimura Y.
ISSN
1468-2060 (Electronic)
ISSN-L
0003-4967
Statut éditorial
Publié
Date de publication
2010
Volume
69
Numéro
8
Pages
1479-1483
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
OBJECTIVES: To determine whether baseline demographic, clinical, articular and laboratory variables predict methotrexate (MTX) poor response in polyarticular-course juvenile idiopathic arthritis.
METHODS: Patients newly treated for 6 months with MTX enrolled in the Paediatric Rheumatology International Trials Organization (PRINTO) MTX trial. Bivariate and logistic regression analyses were used to identify baseline predictors of poor response according to the American College of Rheumatology pediatric (ACR-ped) 30 and 70 criteria.
RESULTS: In all, 405/563 (71.9%) of patients were women; median age at onset and disease duration were 4.3 and 1.4 years, respectively, with anti-nuclear antibody (ANA) detected in 259/537 (48.2%) patients. With multivariate logistic regression analysis, the most important determinants of ACR-ped 70 non-responders were: disease duration > 1.3 years (OR 1.93), ANA negativity (OR 1.77), Childhood Health Assessment Questionnaire (CHAQ) disability index > 1.125 (OR 1.65) and the presence of right and left wrist activity (OR 1.55). Predictors of ACR-ped 30 non-responders were: ANA negativity (OR 1.92), CHAQ disability index > 1.14 (OR 2.18) and a parent's evaluation of child's overall well-being < or = 4.69 (OR 2.2).
CONCLUSION: The subgroup of patients with longer disease duration, ANA negativity, higher disability and presence of wrist activity were significantly associated with a poorer response to a 6-month MTX course.
Mots-clé
Adolescent, Antibodies, Antinuclear/analysis, Antirheumatic Agents/therapeutic use, Arthritis, Juvenile Rheumatoid/drug therapy, Arthritis, Juvenile Rheumatoid/immunology, Child, Child, Preschool, Disability Evaluation, Female, Follow-Up Studies, Humans, Immunosuppressive Agents/therapeutic use, Male, Methotrexate/therapeutic use, Prognosis, Treatment Outcome
Pubmed
Web of science
Création de la notice
31/01/2011 16:33
Dernière modification de la notice
20/08/2019 15:02
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