Detection and measurement of paracaspase MALT1 activity.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_9AC18801792B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Detection and measurement of paracaspase MALT1 activity.
Périodique
Methods in Molecular Biology
Auteur(s)
Hailfinger S., Pelzer C., Thome M.
ISSN
1940-6029 (Electronic)
ISSN-L
1064-3745
Statut éditorial
Publié
Date de publication
2014
Volume
1133
Pages
177-188
Langue
anglais
Résumé
The paracaspase MALT1 is a Cys-dependent, Arg-specific protease that plays an essential role in the activation and proliferation of lymphocytes during the immune response. Oncogenic activation of MALT1 is associated with the development of specific forms of B-cell lymphomas. Through specific cleavage of its substrates, MALT1 controls various aspects of lymphocyte activation, including the activation of transcriptional pathways, the stabilization of mRNAs, and an increase in cellular adhesion. In lymphocytes, the activity of MALT1 is tightly controlled by its inducible monoubiquitination, which promotes the dimerization of MALT1. Here, we describe both in vitro and in vivo assays that have been developed to assess MALT1 activity.
Mots-clé
Immunomodulation, NF-kB, Lymphocyte activation, Lymphoma
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/06/2014 9:53
Dernière modification de la notice
20/08/2019 16:01
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