Synchronizability of EEG-Based Functional Networks in Early Alzheimer's Disease.

Détails

ID Serval
serval:BIB_9AB510ADA0BE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Synchronizability of EEG-Based Functional Networks in Early Alzheimer's Disease.
Périodique
IEEE Transactions on Neural Systems and Rehabilitation Engineering
Auteur⸱e⸱s
Tahaei M.S., Jalili M., Knyazeva M.G.
ISSN
1558-0210 (Electronic)
ISSN-L
1534-4320
Statut éditorial
Publié
Date de publication
2012
Volume
20
Numéro
5
Pages
636-641
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Recently graph theory and complex networks have been widely used as a mean to model functionality of the brain. Among different neuroimaging techniques available for constructing the brain functional networks, electroencephalography (EEG) with its high temporal resolution is a useful instrument of the analysis of functional interdependencies between different brain regions. Alzheimer's disease (AD) is a neurodegenerative disease, which leads to substantial cognitive decline, and eventually, dementia in aged people. To achieve a deeper insight into the behavior of functional cerebral networks in AD, here we study their synchronizability in 17 newly diagnosed AD patients compared to 17 healthy control subjects at no-task, eyes-closed condition. The cross-correlation of artifact-free EEGs was used to construct brain functional networks. The extracted networks were then tested for their synchronization properties by calculating the eigenratio of the Laplacian matrix of the connection graph, i.e., the largest eigenvalue divided by the second smallest one. In AD patients, we found an increase in the eigenratio, i.e., a decrease in the synchronizability of brain networks across delta, alpha, beta, and gamma EEG frequencies within the wide range of network costs. The finding indicates the destruction of functional brain networks in early AD.
Pubmed
Web of science
Création de la notice
04/10/2012 18:04
Dernière modification de la notice
20/08/2019 16:01
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