Cefuroxime prophylaxis is effective in noninstrumented spine surgery: a double-blind, placebo-controlled study.

Détails

ID Serval
serval:BIB_9A805791271F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Cefuroxime prophylaxis is effective in noninstrumented spine surgery: a double-blind, placebo-controlled study.
Périodique
Spine
Auteur(s)
Petignat C., Francioli P., Harbarth S., Regli L., Porchet F., Reverdin A., Rilliet B., de Tribolet N., Pannatier A., Pittet D., Zanetti G.
ISSN
1528-1159
Statut éditorial
Publié
Date de publication
08/2008
Peer-reviewed
Oui
Volume
33
Numéro
18
Pages
1919-1924
Langue
anglais
Résumé
STUDY DESIGN: Double-blind, placebo-controlled randomized clinical trial. OBJECTIVE: To assess the efficacy of 1 preoperative 1.5 g dose of cefuroxime in preventing surgical site infection after surgery for herniated disc. SUMMARY OF BACKGROUND DATA: Antibiotic prophylaxis was only tested in nonconclusive trials in this setting. METHODS: The study was conducted in 2 university hospitals in Switzerland. Patients were assessed for occurrence of surgical site infection (defined by the criteria of the Centers for Diseases Control and Prevention), other infections, or adverse events up to 6 months after surgery. Outcome measures were compared in a univariate, per-protocol analysis. RESULTS: Baseline characteristics were similar in patients allocated to cefuroxime (n = 613) or placebo (n = 624). Eight (1.3%) patients in the cefuroxime group and 18 patients (2.8%) in the placebo group developed a surgical site infection (P = 0.073). A diagnosis of spondylodiscitis or epidural abscess was made in 9 patients in the placebo group, but none in the cefuroxime group (P < 0.01), which corresponded to a number necessary to treat of 69 patients to prevent one of these infections. There were no significant adverse events attributed to either cefuroxime or placebo. CONCLUSION: A single, preoperative dose of cefuroxime significantly reduces the risk of organ-space infection, most notably spondylodiscitis, after surgery for herniated disc.
Mots-clé
Adolescent, Adult, Aged, Aged, 80 and over, Antibiotic Prophylaxis, Cefuroxime, Double-Blind Method, Female, Humans, Intervertebral Disk Displacement, Male, Middle Aged, Neurosurgical Procedures, Surgical Wound Infection
Pubmed
Web of science
Création de la notice
05/03/2009 16:13
Dernière modification de la notice
20/08/2019 16:01
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