Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.

Détails

ID Serval
serval:BIB_99283D45E0DD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.
Périodique
Nature Immunology
Auteur⸱e⸱s
Soumelis V., Reche P.A., Kanzler H., Yuan W., Edward G., Homey B., Gilliet M., Ho S., Antonenko S., Lauerma A., Smith K., Gorman D., Zurawski S., Abrams J., Menon S., McClanahan T., de Waal-Malefyt Rd R., Bazan F., Kastelein R.A., Liu Y.J.
ISSN
1529-2908 (Print)
ISSN-L
1529-2908
Statut éditorial
Publié
Date de publication
2002
Volume
3
Numéro
7
Pages
673-680
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Whether epithelial cells play a role in triggering the immune cascade leading to T helper 2 (T(H)2)-type allergic inflammation is not known. We show here that human thymic stromal lymphopoietin (TSLP) potently activated CD11c(+) dendritic cells (DCs) and induced production of the T(H)2-attracting chemokines TARC (thymus and activation-regulated chemokine; also known as CCL17) and MDC (macrophage-derived chemokine; CCL22). TSLP-activated DCs primed naïve T(H) cells to produce the proallergic cytokines interleukin 4 (IL-4), IL-5, IL-13 and tumor necrosis factor-alpha, while down-regulating IL-10 and interferon-gamma. TSLP was highly expressed by epithelial cells, especially keratinocytes from patients with atopic dermatitis. TSLP expression was associated with Langerhans cell migration and activation in situ. These findings shed new light on the function of human TSLP and the role played by epithelial cells and DCs in initiating allergic inflammation.
Mots-clé
Adult, Antigens, CD11, Biological Markers, CD4-Positive T-Lymphocytes/cytology, CD4-Positive T-Lymphocytes/immunology, Cell Division, Cells, Cultured, Coculture Techniques, Cytokines/genetics, Cytokines/immunology, Dendritic Cells/cytology, Dendritic Cells/drug effects, Dermatitis, Atopic/immunology, Dermatitis, Atopic/pathology, Epithelial Cells/cytology, Epithelial Cells/immunology, Gene Expression, Humans, Interleukin-7/immunology, Interleukin-7/pharmacology, Langerhans Cells/cytology, Langerhans Cells/immunology, Palatine Tonsil/immunology, RNA, Messenger, Skin/immunology, Skin/pathology, Th2 Cells/cytology, Th2 Cells/immunology, Thymus Gland/immunology
Pubmed
Web of science
Création de la notice
19/11/2012 19:32
Dernière modification de la notice
20/08/2019 16:00
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