Diagnostic role of radiolabelled choline PET or PET/CT in hepatocellular carcinoma: a systematic review and meta-analysis.

Détails

ID Serval
serval:BIB_991E5E63D560
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Diagnostic role of radiolabelled choline PET or PET/CT in hepatocellular carcinoma: a systematic review and meta-analysis.
Périodique
Hepatology international
Auteur⸱e⸱s
Bertagna F., Bertoli M., Bosio G., Biasiotto G., Sadeghi R., Giubbini R., Treglia G.
ISSN
1936-0541 (Electronic)
ISSN-L
1936-0533
Statut éditorial
Publié
Date de publication
10/2014
Peer-reviewed
Oui
Volume
8
Numéro
4
Pages
493-500
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The role of fluorine-18-fluorodeoxygluose positron emission tomography/computed tomography ((18)F-FDG PET/CT) in hepatocellular carcinoma (HCC) has not been firmly established yet and its sensitivity has been reported to be in the range of 40-60 %. Because of this relatively low sensitivity alternative tracers have been proposed. The aim of our review is to analyse the literature data on the diagnostic role of (18)F/(11)C-choline PET/CT in the evaluation of HCC. A comprehensive computer literature search of PubMed/MEDLINE, Embase and Scopus databases was conducted to find relevant published articles about the role of whole-body (18)F-choline or (11)C-choline PET or PET/CT in patients with HCC. Furthermore, a meta-analysis about the detection rate of this method in HCC was performed. Six articles were included in this systematic review and discussed. The meta-analysis of five out of six articles showed a DR of 84 % (95 % CI 79-89 %). The DR increased when poorly differentiated HCC was excluded from the analysis. Radiolabelled choline PET or PET/CT could be a valuable tool in detecting HCC and it is better than (18)F-FDG PET/CT, especially in well to moderately differentiated lesions; on the other hand, poorly differentiated and higher-stage HCC could be better evaluated with (18)F-FDG and dual tracer imaging should be considered and could be potentially useful to increase accuracy.

Mots-clé
11C-choline, 18F-choline, HCC, Hepatocellular carcinoma, PET/CT
Pubmed
Web of science
Création de la notice
20/08/2017 16:52
Dernière modification de la notice
20/08/2019 15:00
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