Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus.

Détails

ID Serval
serval:BIB_98F5BE651602
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus.
Périodique
PLoS biology
Auteur(s)
Jessberger S., Aigner S., Clemenson G.D., Toni N., Lie D.C., Karalay O., Overall R., Kempermann G., Gage F.H.
ISSN
1545-7885[electronic]
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
6
Numéro
11
Pages
e272
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
Newborn granule cells become functionally integrated into the synaptic circuitry of the adult dentate gyrus after a morphological and electrophysiological maturation process. The molecular mechanisms by which immature neurons and the neurites extending from them find their appropriate position and target area remain largely unknown. Here we show that single-cell-specific knockdown of cyclin-dependent kinase 5 (cdk5) activity in newborn cells using a retrovirus-based strategy leads to aberrant growth of dendritic processes, which is associated with an altered migration pattern of newborn cells. Even though spine formation and maturation are reduced in cdk5-deficient cells, aberrant dendrites form ectopic synapses onto hilar neurons. These observations identify cdk5 to be critically involved in the maturation and dendrite extension of newborn neurons in the course of adult neurogenesis. The data presented here also suggest a mechanistic dissociation between accurate dendritic targeting and subsequent synapse formation.
Mots-clé
Adult Stem Cells/cytology, Animals, Cell Differentiation, Cyclin-Dependent Kinase 5/genetics, Cyclin-Dependent Kinase 5/metabolism, Dendrites/physiology, Dentate Gyrus/cytology, Female, Gene Expression Regulation, Developmental, Hippocampus/cytology, Humans, Mice, Mice, Inbred C57BL, Neurogenesis, Neurons/cytology, Neurons/physiology, Rats, Retroviridae/genetics, Synapses/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/01/2010 8:43
Dernière modification de la notice
20/08/2019 16:00
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