Severe cytomegalovirus infection in multiply transfused, splenectomized, trauma patients

Détails

ID Serval
serval:BIB_98D859D2DDB6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Severe cytomegalovirus infection in multiply transfused, splenectomized, trauma patients
Périodique
Lancet
Auteur(s)
Baumgartner  J. D., Glauser  M. P., Burgo-Black  A. L., Black  R. D., Pyndiah  N., Chiolero  R.
ISSN
0140-6736
Statut éditorial
Publié
Date de publication
07/1982
Peer-reviewed
Oui
Volume
2
Numéro
8289
Pages
63-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul 10
Résumé
During a 2-year period 5 previously healthy young men who had undergone splenectomy and received multiple transfusions for trauma had severe cytomegalovirus (CMV) infection. Their illness was characterised by a long period of high fever, severe interstitial pneumonitis with dyspnoea and hypoxaemia, and an unusually high lymphocytosis (12 000-26 000 cells/microliter) with numerous atypical forms. The presumptive diagnosis was based on the patients' seroconversion and viral excretion, on the clinical and haematological findings which were typical of severe CMV infection, and on the absence of other infective organisms. In 1 case widespread CMV pneumonitis was confirmed at necropsy. These observations raise the possibility that splenectomy increases the severity and modifies the pattern of CMV infection, since during the same period no other case of severe CMV infection was observed among a large number of patients who had received multiple transfusions but had not undergone splenectomy.
Mots-clé
Abdominal Injuries/surgery Acute Disease Adult Aged *Blood Transfusion Cytomegalovirus Infections/*etiology/immunology Humans Immunity, Cellular Lymphocytosis/etiology Male Postoperative Complications Pulmonary Fibrosis/etiology Spleen/immunology Splenectomy/*adverse effects Thoracic Injuries/surgery Wounds and Injuries/*complications
Pubmed
Web of science
Création de la notice
19/01/2008 19:12
Dernière modification de la notice
20/08/2019 16:00
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