Blood pressure maintenance in awake dehydrated rats: renin, vasopressin, and sympathetic activity

Détails

ID Serval
serval:BIB_98C3E458F2EF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Blood pressure maintenance in awake dehydrated rats: renin, vasopressin, and sympathetic activity
Périodique
American Journal of Physiology. Heart and Circulatory Physiology
Auteur⸱e⸱s
Burnier  M., Biollaz  J., Brunner  D. B., Brunner  H. R.
ISSN
0363-6135
Statut éditorial
Publié
Date de publication
08/1983
Volume
245
Numéro
2
Pages
H203-9
Notes
Journal Article --- Old month value: Aug
Résumé
The role of vasopressin, the renin system, and sympathetic activity in sustaining blood pressure in the dehydrated state was investigated in normotensive nonanesthetized male Wistar rats. After 48-h dehydration, plasma arginine vasopressin was 14.0 +/- 1.7 pg/ml and plasma norepinephrine 0.46 +/- 0.05 ng/ml. In another group of rats in which the angiotensin converting enzyme inhibitor (MK 421, 5 mg po twice daily) was administered throughout the dehydration period, blood pressure was reduced by more than 20% (P less than 0.001), and both plasma arginine vasopressin and norepinephrine were higher at 23.4 +/- 3.9 pg/ml (P less than 0.01) and 0.83 +/- 0.07 ng/ml (P less than 0.01), respectively. Taken together, in rats with or without converting enzyme blockade, there was an inverse correlation between mean blood pressure and plasma arginine vasopressin (r = 0.67, P less than 0.01) as well as plasma norepinephrine (r = 0.82, P less than 0.01) levels. The acute administration of a specific vasopressin pressor inhibitor (dPVDAVP) reduced mean blood pressure in the rats with a blocked renin system by 16.9 mmHg (P less than 0.001). In rats without converting enzyme inhibition, the induced fall was only 6.4 mmHg. These results indicate that following 48-h dehydration the renin angiotensin system interacts with the vasopressin secretory mechanism to sustain blood pressure, with renin playing a predominant role. They further suggest that, following blockade of the renin system, activation of the sympathetic nervous system probably also contributes to blood pressure maintenance.
Mots-clé
Angiotensin-Converting Enzyme Inhibitors Animals Arginine Vasopressin/*blood *Blood Pressure/drug effects Dehydration/*physiopathology Dipeptides/pharmacology Enalapril Epinephrine/blood Heart Rate/drug effects Lysine Vasopressin/pharmacology Male Norepinephrine/*blood Peptidyl-Dipeptidase A/blood Rats Rats, Inbred Strains Renin/*blood Wakefulness/*physiology
Pubmed
Web of science
Création de la notice
25/01/2008 13:55
Dernière modification de la notice
20/08/2019 16:00
Données d'usage