Integrins, endometrial maturation, & human embryo implantation.

Détails

ID Serval
serval:BIB_9851A56DBC93
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Integrins, endometrial maturation, & human embryo implantation.
Périodique
Seminars in Reproductive Endocrinology
Auteur(s)
Coutifaris C., Omigbodun A., Coukos G.
ISSN
0734-8630 (Print)
ISSN-L
0734-8630
Statut éditorial
Publié
Date de publication
1998
Volume
16
Numéro
3
Pages
219-229
Langue
anglais
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Résumé
Cell-cell and cell-extracellular matrix interactions are fundamental processes involved in cell migration and tissue remodeling. Both the cyclic regeneration of the human endometrium during the menstrual cycle as well as the process of embryo implantation involve such dynamic interactions. It has become quite clear that integrin adhesion molecules expressed on the surface of cells play critical roles in the transmission of signals from the extracellular milieu to the cells. It is these signals that presumably regulate the behavior of these cells during major morphogenetic processes. In recent years, work in human endometrium and trophoblasts has uncovered both the regulated and constitutive expression of integrin subunits and their extracellular matrix ligands in these tissues. In addition, attempts have been made to correlate pathological states related to either infertility or abnormal pregnancy to the aberrant expression of several of these integrins. The purpose of the present review is to describe briefly our present state of knowledge of the expression of integrins in human endometrium and trophoblasts and provide the reader with the necessary background needed to understand, at the cellular and molecular levels, processes in reproduction such as embryo implantation.
Mots-clé
Embryo Implantation/physiology, Embryonic and Fetal Development/physiology, Endometrium/physiology, Female, Gene Expression, Humans, Integrins/biosynthesis, Integrins/physiology, Menstrual Cycle/physiology, Pregnancy, Signal Transduction, Trophoblasts/physiology
Pubmed
Création de la notice
14/10/2014 12:43
Dernière modification de la notice
20/08/2019 16:00
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