Blood coagulation in postmenopausal women given estrogen treatment: comparison of transdermal and oral administration

Détails

ID Serval
serval:BIB_98350248F4B3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Blood coagulation in postmenopausal women given estrogen treatment: comparison of transdermal and oral administration
Périodique
Journal of Laboratory and Clinical Medicine
Auteur⸱e⸱s
Alkjaersig  N., Fletcher  A. P., de Ziegler  D., Steingold  K. A., Meldrum  D. R., Judd  H. L.
ISSN
0022-2143
Statut éditorial
Publié
Date de publication
02/1988
Peer-reviewed
Oui
Volume
111
Numéro
2
Pages
224-8
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Feb
Résumé
The responses of the blood coagulation and related systems were studied in 23 postmenopausal women, all of whom received, in randomized order, therapy with conjugated oral estrogens (0.625 and 1.25 mg daily) and transdermally administered estradiol in doses of 25, 50, 100, and 200 micrograms/24 hr. Neither plasma fibrinopeptide A determinations nor plasma fibrinogen chromatographic findings were altered; thus there is no evidence of accelerated fibrinogen turnover with either form of therapy. However, alpha 1-antitrypsin and plasminogen concentrations were significantly increased with the higher dosage of oral but not with transdermally administered estrogen. Similarly, ceruloplasmin concentration was significantly elevated with both oral doses but was unchanged by transdermal therapy.
Mots-clé
Administration, Cutaneous Administration, Oral Blood Coagulation/*drug effects Ceruloplasmin/analysis Estradiol/administration & dosage/*pharmacology Factor VIII/analysis Female Humans *Menopause Plasminogen/analysis Radioimmunoassay alpha 1-Antitrypsin/analysis alpha-Macroglobulins/analysis
Pubmed
Web of science
Création de la notice
28/02/2008 11:36
Dernière modification de la notice
20/08/2019 14:59
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