Effects of amino acids on glucose disposal

Détails

ID Serval
serval:BIB_98318AEFEBCB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effects of amino acids on glucose disposal
Périodique
Diabetes
Auteur(s)
Boden  G., Tappy  L.
ISSN
0012-1797 (Print)
Statut éditorial
Publié
Date de publication
09/1990
Volume
39
Numéro
9
Pages
1079-84
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Sep
Résumé
Free fatty acids are known to inhibit carbohydrate disposal and oxidation. This action may play an important role in the pathophysiology of insulin resistance and non-insulin-dependent diabetes mellitus. To investigate whether amino acids (AAs) have similar actions, we determined the effects of an intravenously infused mixture of 15 AAs on carbohydrate disposal during euglycemic-hyperinsulinemic clamps associated with either basal or high glucagon concentrations in healthy male volunteers. Plasma glucose concentration was clamped at approximately 4.7 mM (coefficient of variation 4.7%). Insulin infusion (7.18 pmol.kg-1.min-1) raised serum insulin concentrations from 36-50 pM to between 300 and 600 pM. AA infusions (0.5 g.kg-1.h-1.4 h) raised plasma alpha-amino N2 concentrations about five- to six-fold. Infusion of AAs, somatostatin (somatotropin release inhibitory factor, SRIF), and high-glucagon replacement (3.0 ng.kg-1.min-1) reduced the rate of exogenous glucose infusion needed to maintain euglycemia from 51.1 +/- 7.2 mumol.kg-1.min-1 (saline + SRIF + high glucagon) to 28.3 +/- 11.1 mumol.kg-1.min-1 and stimulated endogenous glucose production (from 0 to approximately 17 mumol.kg-1.min-1). Thus, glucose disposal (exogenous infusion plus endogenous production of glucose) remained essentially unchanged. During infusion of AAs + SRIF + basal glucagon replacement (0.25 ng.kg-1.min-1), endogenous glucose production remained completely suppressed, and the rates of exogenous glucose infusion did not change (compared with saline + SRIF + basal glucagon replacement). The data showed that 1) hyperaminoacidemia associated with hyperglucagonemia stimulated endogenous glucose production despite hyperinsulinemia, and 2) intravenous infusion of a mixture of 15 AAs had no inhibitory effect on insulin-stimulated total-body glucose disposal.
Mots-clé
Adult Amino Acids/administration & dosage/*pharmacology Basal Metabolism Blood Glucose/metabolism Carbohydrate Metabolism Glucagon/*blood Glucose/administration & dosage/*metabolism/pharmacology Humans Infusions, Intravenous Insulin/blood/pharmacology Male Oxidation-Reduction/drug effects Somatostatin/blood
Pubmed
Web of science
Création de la notice
24/01/2008 14:36
Dernière modification de la notice
20/08/2019 15:59
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