Restoration of anti-tetanus toxoid responses in patients initiating highly active antiretroviral therapy with or without a boost immunization: an INITIO substudy.

Détails

ID Serval
serval:BIB_97E9B91E59FD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Restoration of anti-tetanus toxoid responses in patients initiating highly active antiretroviral therapy with or without a boost immunization: an INITIO substudy.
Périodique
Clinical and Experimental Immunology
Auteur⸱e⸱s
Burton C.T., Goodall R.L., Samri A., Autran B., Kelleher A.D., Poli G., Pantaleo G., Gotch F.M., Imami N.
ISSN
1365-2249[electronic]
Statut éditorial
Publié
Date de publication
2008
Volume
152
Numéro
2
Pages
252-257
Langue
anglais
Résumé
INITIO is an open-labelled randomized trial evaluating first-line therapeutic strategies for human immunodeficiency virus-1 (HIV-1) infection. In an immunology substudy a tetanus toxoid booster (TTB) immunization was planned for 24 weeks after initiation of highly active antiretroviral therapy (HAART). All patients had received tetanus toxoid immunization in childhood. Generation of proliferative responses to tetanus toxoid was compared in two groups of patients, those receiving a protease inhibitor (PI)-sparing regimen (n = 21) and those receiving a PI-containing (n = 54) regimen. Fifty-two participants received a TTB immunization [PI-sparing (n = 15), PI-containing (n = 37)] and 23 participants did not [PI-sparing (n = 6) or PI-containing (n = 17)]. Cellular responses to tetanus antigen were monitored by lymphoproliferation at time of immunization and every 24 weeks to week 156. Proportions with a positive response (defined as stimulation index > or = 3 and Delta counts per minute > or = 3000) were compared at weeks 96 and 156. All analyses were intent-to-treat. Fifty-two participants had a TTB immunization at median 25 weeks; 23 patients did not. At weeks 96 and 156 there was no evidence of a difference in tetanus-specific responses, between those with or without TTB immunization (P = 0.2, P = 0.4). There was no difference in the proportion with response between those with PI-sparing or PI-containing regimens at both time-points (P = 0.8, P = 0.7). The proliferative response to tetanus toxoid was unaffected by initial HAART regimen. Anti-tetanus responses appear to reconstitute eventually in most patients over 156 weeks when treated successfully with HAART, irrespective of whether or not a TTB immunization has been administered.
Mots-clé
Anti-HIV Agents, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, Cell Proliferation, HIV Infections, HIV-1, Humans, Immunity, Cellular, Immunization, Immunization, Secondary, Lymphocyte Activation, Tetanus Toxoid, Viral Load
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/03/2009 10:30
Dernière modification de la notice
20/08/2019 14:59
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