[Blood pressure and renin activity in essential hypertension under pindolol]

Détails

ID Serval
serval:BIB_97933248EBC4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
[Blood pressure and renin activity in essential hypertension under pindolol]
Périodique
Schweizerische Medizinische Wochenschrift
Auteur(s)
Nussberger  J., Vetter  W., Furrer  J., Beckerhoff  R., Wursten  D., Schmied  U., Siegenthaler  W.
ISSN
0036-7672 (Print)
Statut éditorial
Publié
Date de publication
06/1976
Volume
106
Numéro
24
Pages
831-4
Notes
English Abstract
Journal Article --- Old month value: Jun 12
Résumé
20 essential hypertension patients with diastolic blood pressure of 100-140 mm Hg were treated with increasing doses (15-45 mg/day by mouth) of pindolol for 14 weeks after an initial placebo period of 5 weeks. Systolic and diastolic blood pressure decreased significantly with as little as 15 mg of pindolol (p less than 0.001). No further changes in systolic and diastolic blood pressure were observed when the doses of pindolol were increased. Plasma renin activity (PRA) determined by radioimmunoassay did not change under increasing doses of pindolol. The blood pressure changes did not correlate with initial PRA or with individual changes in PRA under increasing doses with individual changes in PRA under increasing doses of pindolol. These results do not afford evidence for a renin-dependent hypotensive effect of pindolol.
Mots-clé
Adolescent Adult Blood Pressure Body Weight Female Heart Rate Humans Hypertension/drug therapy/*physiopathology Male Middle Aged Pindolol/*therapeutic use Renin/blood Sodium/urine
Pubmed
Web of science
Création de la notice
05/03/2008 16:41
Dernière modification de la notice
20/08/2019 14:59
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