Longitudinal prospective study of matrix metalloproteinase-9 as a serum marker in gliomas.

Détails

ID Serval
serval:BIB_976E612943E9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Longitudinal prospective study of matrix metalloproteinase-9 as a serum marker in gliomas.
Périodique
Journal of Neuro-oncology
Auteur⸱e⸱s
Iwamoto F.M., Hottinger A.F., Karimi S., Riedel E., Dantis J., Jahdi M., Panageas K.S., Lassman A.B., Abrey L.E., Fleisher M., Deangelis L.M., Holland E.C., Hormigo A.
ISSN
1573-7373 (Electronic)
ISSN-L
0167-594X
Statut éditorial
Publié
Date de publication
2011
Volume
105
Numéro
3
Pages
607-612
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The objective of this study was to evaluate if longitudinal measurements of serum matrix metalloproteinase-9 (MMP-9) correlated with disease status or survival in adults with gliomas. Serum samples were collected prospectively and concurrently with MRI scans at multiple time points during the course of the disease. MMP-9 levels were determined by ELISA and correlated with radiographic disease status and survival. Forty-one patients with low-grade gliomas, 105 with anaplastic gliomas, and 197 with glioblastoma enrolled in this study from August 2002 to September 2008. A total of 1,684 serum samples (97.1% of all MMP-9 samples) had a matching MRI scan. No statistically significant association was observed between levels of serum MMP-9 and radiographic disease status in low-grade gliomas (P = 0.98), anaplastic gliomas (P = 0.39) or glioblastomas (P = 0.33). Among patients with glioblastoma, longitudinal increases in MMP-9 had a weak association with shorter survival (HR = 1.1 per each doubling in MMP-9 levels, 95% CI, 1.0-1.3, P = 0.04) but they were not independently associated with survival when adjusted for age, extent of resection, and performance status. Changes in serum MMP-9 were not associated with survival in the anaplastic glioma cohort. Serum MMP-9 showed no utility in determining glioma disease status and was not a clinically relevant prognostic marker of survival.
Mots-clé
Adult, Brain Neoplasms/blood, Brain Neoplasms/mortality, Enzyme-Linked Immunosorbent Assay, Female, Glioma/blood, Glioma/mortality, Humans, Kaplan-Meier Estimate, Longitudinal Studies, Male, Matrix Metalloproteinase 9/blood, Prognosis, Proportional Hazards Models, Prospective Studies, Tumor Markers, Biological/blood
Pubmed
Création de la notice
19/02/2014 21:25
Dernière modification de la notice
20/08/2019 14:59
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