Impact of chemical exposure on cancer mortality in a French cohort of uranium processing workers

Détails

ID Serval
serval:BIB_96DDB23F719D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Impact of chemical exposure on cancer mortality in a French cohort of uranium processing workers
Périodique
American Journal of Industrial Medicine
Auteur(s)
Zhivin Sergey, Laurier Dominique, Caër-Lorho Sylvaine, Acker Alain, Guseva Canu Irina
ISSN
1097-0274 (Electronic)
ISSN-L
0271-3586
Statut éditorial
Publié
Date de publication
11/2013
Peer-reviewed
Oui
Volume
56
Numéro
11
Pages
1262-1271
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Nuclear workers may be exposed to a variety of chemical hazards, in addition to radiation. We examined the effect of chemical exposures on cancer mortality among French uranium processing workers at the AREVA NC Pierrelatte facility.
A cohort of 2,897 uranium processing workers employed for at least 6 months was followed from 1968 through 2006. Exposure to uranium and potentially carcinogenic chemicals was assessed with a plant-specific job-exposure matrix. Mortality hazard ratios (HRs) for cancers of the lung, lymphohematopoietic system, kidney and bladder, brain and central nervous system (BCNS), and prostate were estimated for each specific chemical exposure, with Cox regression models stratified for sex and calendar period and adjusted for socioeconomic status. Additional adjustments enabled us to examine the effect of co-exposure to uranium and other chemicals.
Exposure to aromatic solvents was associated with increased risk of BCNS malignancies after adjustment for other chemicals (HR=6.53, 95% CI=1.14-37.41; n=6) and for other chemicals and uranium (HR=7.26, 95% CI=0.90-58.19) in the annual exposure status model. Selected groups of lymphohematopoietic cancers were found associated with solvent exposure. Inconclusive results were found regarding chromium (VI) exposure, since only 2 workers died from lung cancer among 109 exposed.
Based on our pilot study, it seemed important to take into account chemical exposures in the analyses of cancer mortality among French uranium processing workers.

Mots-clé
Asbestos/poisoning, Carcinogens, Central Nervous System Neoplasms/mortality, Chromium Compounds/poisoning, Cohort Studies, Extraction and Processing Industry, Female, France, Hazardous Substances/poisoning, Hematologic Neoplasms/mortality, Humans, Kidney Neoplasms/mortality, Longitudinal Studies, Lung Neoplasms/mortality, Male, Middle Aged, Neoplasms/mortality, Neoplasms, Radiation-Induced/mortality, Occupational Diseases/mortality, Occupational Exposure, Proportional Hazards Models, Prostatic Neoplasms/mortality, Solvents/poisoning, Uranium/poisoning, Urinary Bladder Neoplasms/mortality, chemicals, chromium, epidemiology, ionizing radiation, nuclear workers, solvents, uranium
Pubmed
Web of science
Création de la notice
12/09/2017 14:01
Dernière modification de la notice
20/08/2019 15:58
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