Pulmonary-artery pressure and exhaled nitric oxide in Bolivian and Caucasian high altitude dwellers.

Détails

ID Serval
serval:BIB_96D78AEF99D1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Pulmonary-artery pressure and exhaled nitric oxide in Bolivian and Caucasian high altitude dwellers.
Périodique
High Altitude Medicine and Biology
Auteur⸱e⸱s
Schwab M., Jayet P.Y., Stuber T., Salinas C.E., Bloch J., Spielvogel H., Villena M., Allemann Y., Sartori C., Scherrer U.
ISSN
1527-0297 (Print)
ISSN-L
1527-0297
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
9
Numéro
4
Pages
295-299
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
There is evidence that high altitude populations may be better protected from hypoxic pulmonary hypertension than low altitude natives, but the underlying mechanism is incompletely understood. In Tibetans, increased pulmonary respiratory NO synthesis attenuates hypoxic pulmonary hypertension. It has been speculated that this mechanism may represent a generalized high altitude adaptation pattern, but direct evidence for this speculation is lacking. We therefore measured systolic pulmonary-artery pressure (Doppler chocardiography) and exhaled nitric oxide (NO) in 34 healthy, middle-aged Bolivian high altitude natives and in 34 age- and sex-matched, well-acclimatized Caucasian low altitude natives living at high altitude (3600 m). The mean+/-SD systolic right ventricular to right atrial pressure gradient (24.3+/-5.9 vs. 24.7+/-4.9 mmHg) and exhaled NO (19.2+/-7.2 vs. 22.5+/-9.5 ppb) were similar in Bolivians and Caucasians. There was no relationship between pulmonary-artery pressure and respiratory NO in the two groups. These findings provide no evidence that Bolivian high altitude natives are better protected from hypoxic pulmonary hypertension than Caucasian low altitude natives and suggest that attenuation of pulmonary hypertension by increased respiratory NO synthesis may not represent a universal adaptation pattern in highaltitude populations.
Mots-clé
Acclimatization/physiology, Adult, Altitude, Blood Pressure/physiology, Bolivia, Environmental Monitoring, European Continental Ancestry Group, Humans, Hypertension, Pulmonary/diagnosis, Hypertension, Pulmonary/ethnology, Indians, South American, Male, Nitric Oxide/metabolism, Oximetry, Pulmonary Artery/physiology, Risk Factors
Pubmed
Web of science
Création de la notice
16/01/2009 15:28
Dernière modification de la notice
20/08/2019 14:58
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