Efficient photodynamic therapy of cancer using chemotherapeutic porphyrin-ruthenium metalla-cubes.

Détails

ID Serval
serval:BIB_96CD25906190
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Efficient photodynamic therapy of cancer using chemotherapeutic porphyrin-ruthenium metalla-cubes.
Périodique
Bioorganic and Medicinal Chemistry Letters
Auteur(s)
Schmitt F., Barry N.P., Juillerat-Jeanneret L., Therrien B.
ISSN
1464-3405 (Electronic)
ISSN-L
0960-894X
Statut éditorial
Publié
Date de publication
2012
Volume
22
Numéro
-
Pages
178-180
Langue
anglais
Résumé
Two cationic octanuclear metalla-cubes [Ru(8)(η(6)-C(6)H(5)Me)(8)(tpp-H2)(2)(dhbq)(4)](8+) and [Ru(8)(η(6)-p-iPrC(6)H(4)Me)(8)(tpp-H2)(2)(dhbq)(4)](8+) were prepared and evaluated as dual photosensitizers and chemotherapeutics in cancer cells. In the dark, the complexes presented high cytotoxicity towards only melanoma and ovarian cancer cells. However, the complexes exhibited good phototoxicities toward all cancer cells (1μM concentration, LD(50)=2-7J/cm(2)), thus suggesting a dual synergistic effect with good properties of both the arene ruthenium chemotherapeutics and the porphyrin photosensitizers.
Pubmed
Web of science
Création de la notice
30/12/2011 12:23
Dernière modification de la notice
20/08/2019 15:58
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