Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration?
Détails
ID Serval
serval:BIB_9686D91B5888
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration?
Périodique
Trends in Pharmacological Sciences
ISSN
0165-6147 (Print)
Statut éditorial
Publié
Date de publication
08/1998
Volume
19
Numéro
8
Pages
328-34
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Aug
Research Support, Non-U.S. Gov't
Review --- Old month value: Aug
Résumé
Increasing evidence indicates that glutamate transporters are vulnerable to the action of biological oxidants, resulting in reduced uptake function. This effect could contribute to the build-up of neurotoxic extracellular glutamate levels, with major pathological consequences. Specific 'redox-sensing' elements, consisting of cysteine residues, have been identified in the structures of at least three transporter subtypes (GLT1, GLAST and EAAC1) and shown to regulate transport rate via thiol-disulphide redox interconversion. In this article, Davide Trotti, Niels Danbolt and Andrea Volterra discuss these findings in relation to the emerging view that in brain diseases oxidative and excitotoxic mechanisms might often operate in tight conjunction to induce neuronal damage. In particular, they review evidence suggesting a possible involvement of oxidative alterations of glutamate transporters in specific pathologies, including amyotrophic lateral sclerosis, Alzheimer's disease, brain trauma and ischaemia.
Mots-clé
Animals
Biological Transport
Glutamates/adverse effects/*metabolism/*physiology
Humans
Neurodegenerative Diseases/pathology
Oxidation-Reduction
Oxidative Stress/physiology
Reactive Oxygen Species/metabolism
Receptors, Glutamate/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 15:37
Dernière modification de la notice
20/08/2019 15:58