Oxygen as a key regulator of cardiomyocyte proliferation: New results about cell culture conditions!

Détails

ID Serval
serval:BIB_9663E3496DD9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Oxygen as a key regulator of cardiomyocyte proliferation: New results about cell culture conditions!
Périodique
Biochimica et biophysica acta. Molecular cell research
Auteur(s)
Bon-Mathier A.C., Rignault-Clerc S., Bielmann C., Rosenblatt-Velin N.
ISSN
1879-2596 (Electronic)
ISSN-L
0167-4889
Statut éditorial
Publié
Date de publication
03/2020
Peer-reviewed
Oui
Volume
1867
Numéro
3
Pages
118460
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
The goal of the new therapeutically strategies aimed to treat cardiovascular diseases (CVDs) is to enhance the natural ability of the heart to regenerate. This represents a great challenge for the coming years as all the mechanisms underlying the replacement of dying cells by functional cells of the same type are not completely elucidated. Among these, stimulating cardiomyocyte proliferation seems to be crucial for the restoration of normal cardiac function after CVDs. In this review, we summarized the recent advances about the modulation of cardiomyocyte proliferation in physiological (during ageing) and pathological conditions. We highlighted the role of oxygen and we presented new results demonstrating that performing neonatal cardiomyocyte cell cultures in "normoxic" oxygen conditions (i.e. 3% oxygen) increases their proliferation rate, when compared to "hyperoxic" conventional conditions (i.e. 20% oxygen). Thus, oxygen concentration seems to be a key factor in the control of cardiomyocyte proliferation.
Mots-clé
Cardiovascular Diseases/metabolism, Cardiovascular Diseases/pathology, Cell Culture Techniques, Cell Cycle/genetics, Cell Proliferation/genetics, Humans, Myocytes, Cardiac/metabolism, Oxygen/metabolism, Signal Transduction/genetics, Cardiomyocyte, Heart, Metabolism, Oxygen, Proliferation, Regeneration
Pubmed
Web of science
Création de la notice
10/04/2019 16:19
Dernière modification de la notice
07/07/2020 5:20
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