A pilot study on the use of a perfluorohexyloctane/silicone oil solution as a heavier than water internal tamponade agent.

Détails

ID Serval
serval:BIB_96317017D623
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A pilot study on the use of a perfluorohexyloctane/silicone oil solution as a heavier than water internal tamponade agent.
Périodique
The British journal of ophthalmology
Auteur⸱e⸱s
Wong D., Van Meurs J.C., Stappler T., Groenewald C., Pearce I.A., McGalliard J.N., Manousakis E., Herbert E.N.
ISSN
0007-1161 (Print)
ISSN-L
0007-1161
Statut éditorial
Publié
Date de publication
06/2005
Peer-reviewed
Oui
Volume
89
Numéro
6
Pages
662-665
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article ; Multicenter Study
Publication Status: ppublish
Résumé
To report a prospective two centred non-comparative interventional pilot study of a solution of perfluorohexyloctane and silicone oil (Densiron-68) as a heavier than water internal tamponade.
42 consecutive patients were recruited. The indications include proliferative vitreoretinopathy, retinal detachments arising from inferior retinal breaks, and inability to posture.
The success rate with one operation using Densiron was 81% and with further surgery 93%. At the end of the study all tamponade agents were removed in 90% of patients. Visual acuity improved from mean logMAR of 1.41 (SD 0.64) to 0.94 (SD 0.57), p = 0.001. There was little evidence of dispersion and excessive inflammation.
This new tamponade agent is being compared to conventional silicone oil in a prospective international randomised trial.
Mots-clé
Adult, Aged, Aged, 80 and over, Drug Combinations, Female, Fluorocarbons/adverse effects, Fluorocarbons/pharmacokinetics, Fluorocarbons/therapeutic use, Humans, Male, Middle Aged, Ocular Hypertension/etiology, Pilot Projects, Postoperative Care/methods, Postoperative Complications, Posture, Prospective Studies, Recurrence, Retinal Detachment/physiopathology, Retinal Detachment/surgery, Silicone Oils/adverse effects, Silicone Oils/pharmacokinetics, Silicone Oils/therapeutic use, Specific Gravity, Treatment Outcome, Visual Acuity, Vitrectomy/methods, Vitreoretinopathy, Proliferative/physiopathology, Vitreoretinopathy, Proliferative/surgery
Pubmed
Web of science
Création de la notice
31/08/2018 10:03
Dernière modification de la notice
20/08/2019 15:58
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