Experimental study on the fractionation schedule for proton irradiation of uveal melanoma
Détails
ID Serval
serval:BIB_95EFA6B4B4CA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Experimental study on the fractionation schedule for proton irradiation of uveal melanoma
Périodique
Graefe's Archive for Clinical and Experimental Ophthalmology
ISSN
0721-832X (Print)
Statut éditorial
Publié
Date de publication
1990
Volume
228
Numéro
6
Pages
562-8
Notes
Journal Article
Résumé
Greene melanoma in the anterior chamber of rabbits was irradiated by protons to find the isoeffect curve for proton irradiation fractionated into one, two, three or four doses. The isoeffect curve for tumor tissue remained constant between one- and three-dose fractionations and rose with four-dose fractionation. The isoeffect curve for normal tissue approximately followed the Ellis equation. Therefore, the optimal irradiation schedule should be in the range of three fractions because this best spares normal tissue while delivering a tumoricidal dose to the lesion. The relative reduction of the total dose from four- to one-dose fractions of intraoperative irradiation should be 20%.
Mots-clé
Animals
Anterior Chamber/radiation effects/ultrastructure
Disease Models, Animal
Female
Follow-Up Studies
Melanoma/*radiotherapy/ultrastructure
Necrosis
Rabbits
Radiotherapy Dosage
Uveal Neoplasms/*radiotherapy/ultrastructure
Pubmed
Web of science
Création de la notice
28/01/2008 13:09
Dernière modification de la notice
20/08/2019 14:58