X-chromosome-wide association study for Alzheimer's disease.
Détails
ID Serval
serval:BIB_95DD4D5D9C2A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
X-chromosome-wide association study for Alzheimer's disease.
Périodique
Molecular psychiatry
Collaborateur⸱rice⸱s
EADB, GR@ACE, DEGESCO, EADI, GERAD, DemGene, FinnGen, ADGC, CHARGE
ISSN
1476-5578 (Electronic)
ISSN-L
1359-4184
Statut éditorial
In Press
Peer-reviewed
Oui
Editeur⸱rice scientifique
Eadb G. R. A. C. E. Degesco Eadi Gerad DemGene FinnGen Adgc Charge
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Publication Status: aheadofprint
Résumé
Due to methodological reasons, the X-chromosome has not been featured in the major genome-wide association studies on Alzheimer's Disease (AD). To address this and better characterize the genetic landscape of AD, we performed an in-depth X-Chromosome-Wide Association Study (XWAS) in 115,841 AD cases or AD proxy cases, including 52,214 clinically-diagnosed AD cases, and 613,671 controls. We considered three approaches to account for the different X-chromosome inactivation (XCI) states in females, i.e. random XCI, skewed XCI, and escape XCI. We did not detect any genome-wide significant signals (P ≤ 5 × 10 <sup>-</sup> <sup>8</sup> ) but identified seven X-chromosome-wide significant loci (P ≤ 1.6 × 10 <sup>-</sup> <sup>6</sup> ). The index variants were common for the Xp22.32, FRMPD4, DMD and Xq25 loci, and rare for the WNK3, PJA1, and DACH2 loci. Overall, this well-powered XWAS found no genetic risk factors for AD on the non-pseudoautosomal region of the X-chromosome, but it identified suggestive signals warranting further investigations.
Pubmed
Open Access
Oui
Création de la notice
09/12/2024 16:47
Dernière modification de la notice
10/12/2024 7:12