Drug-eluting embolic microspheres for local drug delivery - State of the art.

Détails

ID Serval
serval:BIB_95DABA36AF50
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Drug-eluting embolic microspheres for local drug delivery - State of the art.
Périodique
Journal of controlled release
Auteur(s)
Fuchs K., Duran R., Denys A., Bize P.E., Borchard G., Jordan O.
ISSN
1873-4995 (Electronic)
ISSN-L
0168-3659
Statut éditorial
Publié
Date de publication
28/09/2017
Peer-reviewed
Oui
Volume
262
Pages
127-138
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Embolic microspheres or beads used in transarterial chemoembolization are an established treatment method for hepatocellular carcinoma patients. The occlusion of the tumor-feeding vessels by intra-arterial injection of the beads results in tumor necrosis and shrinkage. In this short review, we describe the utility of using these beads as devices for local drug delivery. We review the latest advances in the development of non-biodegradable and biodegradable drug-eluting beads for transarterial chemoembolization. Their capability to load different drugs, such as chemotherapeutics and anti-angiogenic compounds with different physicochemical properties, like charge and hydrophilicity/hydrophobicity, are discussed. We specifically address controlled and sustained drug release from the microspheres, and the resulting in vivo pharmacokinetics in the plasma vs. drug distribution in the targeted tissue.
Mots-clé
Animals, Chemoembolization, Therapeutic, Delayed-Action Preparations/pharmacokinetics, Delayed-Action Preparations/therapeutic use, Drug Delivery Systems, Humans, Microspheres, Antiangiogenic, Bevacizumab (PubChem CID: 24801580), Biodegradable, Cisplatin (PubChem CID 441203), Controlled release, Degradable, Doxorubicin Hydrochloride (PubChem CID: 443939), Drug-eluting beads, Hepatocellular carcinoma, Ibuprofen (PubChem CID: 3672), Irinotecan (PubChem CID: 60838), Local delivery, N-Desethyl Sunitinib (PubChem CID: 10292573), Pharmacokinetics, Rapamycin (PubChem CID: 5284616), Sorafenib (PubChem CID: 216239), Sunitinib (PubChem CID: 5329102), Transarterial chemoembolization, Vandetanib (PubChem CID: 3081361)
Pubmed
Web of science
Création de la notice
02/08/2017 14:18
Dernière modification de la notice
20/08/2019 14:58
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