Survey of human and rat microsatellites.

Détails

ID Serval
serval:BIB_9587B556CEED
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Survey of human and rat microsatellites.
Périodique
Genomics
Auteur⸱e⸱s
Beckman J.S., Weber J.L.
ISSN
0888-7543
Statut éditorial
Publié
Date de publication
04/1992
Peer-reviewed
Oui
Volume
12
Numéro
4
Pages
627-631
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. - Publication Status: ppublish
Résumé
Length variations in simple sequence tandem repeats (microsatellite DNA polymorphisms) are finding increasing usage in mammalian genetics. Although every variety of short tandem repeat that has been tested has been shown to exhibit length polymorphisms, little information on the relative abundance of the different repeat motifs has been collected. In this report, summaries of GenBank searches for all possible human and rat microsatellites ranging from mononucleotide to tetranucleotide repeats are presented. In humans, the five most abundant microsatellites with total lengths for the runs of repeats of greater than or equal to 20 nucleotides contained repeat sequences of A, AC, AAAN, AAN, and AG, in order of decreasing abundance, where N is C, G, or T. These five groups comprised about 76% of all microsatellites. Many other human simple sequence repeats were found at low frequency. In the 745 kb of human genomic DNA surveyed, one microsatellite of greater than or equal to 20 nucleotides in length was found, on average, every 6 kb. Only 12% of the human microsatellites had total lengths greater than or equal to 40 nucleotides. Roughly 80% of the A, AAN, and AAAN microsatellites and 50% of the AT microsatellites, but few of the other human microsatellites, were found to be associated with interspersed, repetitive Alu elements. In rats, the five most abundant microsatellites contained AC, AG, A, AAAN, and AAGG sequences, respectively. Rat microsatellites were generally longer than human microsatellites, with 43% of the rat sequences greater than or equal to 40 nucleotides.
Mots-clé
Animals, Base Sequence, DNA, Satellite/genetics, Databases, Factual, Humans, Rats, Repetitive Sequences, Nucleic Acid, Species Specificity
Pubmed
Web of science
Création de la notice
25/01/2008 16:17
Dernière modification de la notice
20/08/2019 14:57
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