Lipid metabolism in focus: how the build-up and breakdown of lipids affects stem cells.

Détails

ID Serval
serval:BIB_9566E917E0B3
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Lipid metabolism in focus: how the build-up and breakdown of lipids affects stem cells.
Périodique
Development
Auteur(s)
Madsen S., Ramosaj M., Knobloch M.
ISSN
1477-9129 (Electronic)
ISSN-L
0950-1991
Statut éditorial
Publié
Date de publication
15/05/2021
Peer-reviewed
Oui
Volume
148
Numéro
10
Pages
dev191924
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Cellular metabolism has recently emerged as a key regulator of stem cell behavior. Various studies have suggested that metabolic regulatory mechanisms are conserved in different stem cell niches, suggesting a common level of stem cell regulation across tissues. Although the balance between glycolysis and oxidative phosphorylation has been shown to be distinct in stem cells and their differentiated progeny, much less is known about lipid metabolism in stem cell regulation. In this Review, we focus on how stem cells are affected by two major lipid metabolic pathways: the build-up of lipids, called de novo lipogenesis, and the breakdown of lipids, called fatty acid beta-oxidation. We cover the recent literature on hematopoietic stem cells, intestinal stem cells, neural stem/progenitor cells and cancer stem cells, where these two lipid pathways have been studied in more depth.
Mots-clé
Animals, Energy Metabolism/physiology, Fatty Acids/metabolism, Glycolysis/physiology, Hematopoiesis/physiology, Hematopoietic Stem Cells/metabolism, Humans, Lipid Metabolism/physiology, Lipogenesis/physiology, Lipolysis/physiology, Neoplastic Stem Cells/metabolism, Neural Stem Cells/metabolism, Neurogenesis/physiology, Oxidative Phosphorylation, De novo lipogenesis, Cancer stem cells, Fatty acid beta-oxidation, Hematopoietic stem cells, Intestinal stem cells, Lipid metabolism, Neural stem/progenitor cells
Pubmed
Web of science
Financement(s)
Université de Lausanne
Fonds national suisse
Création de la notice
27/05/2021 18:34
Dernière modification de la notice
13/10/2021 6:42
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