Hyperhomocysteinaemia in young patients with non-arteritic anterior ischaemic optic neuropathy.

Détails

ID Serval
serval:BIB_9558AB91810C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Hyperhomocysteinaemia in young patients with non-arteritic anterior ischaemic optic neuropathy.
Périodique
The British journal of ophthalmology
Auteur(s)
Kawasaki A., Purvin V.A., Burgett R.A.
ISSN
0007-1161
Statut éditorial
Publié
Date de publication
1999
Peer-reviewed
Oui
Volume
83
Numéro
11
Pages
1287-90
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
BACKGROUND/AIM: Elevated plasma homocysteine is a newly identified vascular risk factor among patients under age 55 years with cerebrovascular, cardiovascular, or peripheral vascular disease. This study sought to evaluate retrospectively the plasma homocysteine status among healthy younger patients with ischaemic optic disc disease. METHODS: 12 non-diabetic patients who had been diagnosed with non-arteritic anterior ischaemic optic neuropathy (NAION) before the age of 50 years were identified from chart review. None had experienced previous ischaemic cerebrovascular, cardiovascular, or peripheral vascular events. Plasma homocysteine, CBC, renal function, vitamin B6, vitamin B12, and folate levels were sampled in the fasting state. RESULTS: Two of 12 patients (17%) had hyperhomocysteinaemia. Both had experienced NAION in both eyes with recurrent episodes. Neither patient was hypertensive nor had a smoking history. One of these two patients had mild hypercholesterolaemia which did not warrant medication. CONCLUSIONS: Elevated plasma homocysteine may be associated with NAION. An evaluation for hyperhomocysteinaemia should be considered in patients with NAION who do not have the typical risk factor such as older age, diabetes, hypertension, or tobacco use. It should also be considered in young patients with bilateral or recurrent attacks of NAION.
Mots-clé
Adult, Female, Humans, Hyperhomocysteinemia/complications, Ischemia/complications, Male, Middle Aged, Optic Nerve/blood supply, Recurrence, Retrospective Studies, Risk Factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/11/2009 19:09
Dernière modification de la notice
20/08/2019 15:57
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