Indicators of fatal outcome in paediatric cerebral malaria: a study of 134 comatose Papua New Guinean children

Détails

ID Serval
serval:BIB_9516158EB802
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Indicators of fatal outcome in paediatric cerebral malaria: a study of 134 comatose Papua New Guinean children
Périodique
International Journal of Epidemiology
Auteur(s)
Genton  B., al-Yaman  F., Alpers  M. P., Mokela  D.
ISSN
0300-5771 (Print)
Statut éditorial
Publié
Date de publication
06/1997
Volume
26
Numéro
3
Pages
670-6
Notes
Journal Article --- Old month value: Jun
Résumé
BACKGROUND: No comprehensive data on the clinical features and the prognosis of cerebral malaria in the South Pacific are available at present. We conducted a prospective study in children with cerebral malaria to assess the case fatality rate (CFR) in the region and to identify potential risk factors for death. METHODS: We recruited 134 children admitted to the Madang General Hospital between April 1991 and October 1993 with a strictly defined diagnosis of cerebral malaria. Besides clinical examination, we collected a blood sample for parasitological haematological and biochemical assessment. RESULTS: The CFR was 11.9% and the prevalence of residual neurological sequelae at discharge was 1.5%. The proportion of children presenting with deep coma (12%) or hypoglycaemia (17%) was lower in our study than in African ones, where severe complications are more frequent. Also mortality associated with hypoglycaemia on admission was lower. Clinical or laboratory conditions significantly associated with death were deep coma, malarial anaemia and hyperleucocytosis. CONCLUSIONS: All conditions associated with deep coma, such as shock, hypoglycaemia and acidosis, should be corrected. Also prompt administration of blood transfusions to patients with anaemia is likely to reduce the occurrence of death in Papua New Guinean children with cerebral malaria.
Mots-clé
Child Child, Preschool Coma/etiology/mortality Confidence Intervals Cross-Sectional Studies Female Hematocrit/statistics & numerical data Hemoglobins/analysis Humans Infant Leukocyte Count Likelihood Functions Logistic Models Malaria, Cerebral/blood/complications/*mortality/physiopathology Male Odds Ratio Papua New Guinea/epidemiology Prevalence Prospective Studies Severity of Illness Index
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 12:49
Dernière modification de la notice
20/08/2019 15:57
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