Controversies in the Treatment of Peripheral T-cell Lymphoma.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_94EE6E071995
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Controversies in the Treatment of Peripheral T-cell Lymphoma.
Périodique
HemaSphere
Auteur(s)
Bachy E., Broccoli A., Dearden C., de Leval L., Gaulard P., Koch R., Morschhauser F., Trümper L., Zinzani P.L.
ISSN
2572-9241 (Electronic)
ISSN-L
2572-9241
Statut éditorial
Publié
Date de publication
10/2020
Peer-reviewed
Oui
Volume
4
Numéro
5
Pages
e461
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
Peripheral T-cell lymphomas are a heterogeneous group of rare diseases with an aggressive behavior and dismal prognosis. Their classification is complex and still evolving, and several biomolecular markers now help refine the prognosis of specific disease entities, although still have limited impact in tailoring the treatment. First-line treatment strategies can cure only a minority of patients and relapsed-refractory disease still represents the major cause of failure. Frontline autologous transplantation may have an impact in the consolidation of response; however, its role is still questioned as far as complete responses obtained after induction chemotherapy are concerned. Newer drugs are now being evaluated in clinical trials, but effective salvage strategies for those who experience treatment failures are lacking. Here we review and discuss the most controversial aspects of diagnosis and treatment of peripheral T-cell lymphomas.
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/10/2020 13:43
Dernière modification de la notice
03/02/2021 8:09
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