Asymmetrical pre-synaptic and post-synpatic changes in the striatal dopamine projection in dopa naïve parkinsonism. Diagnostic implications of the D2 receptor status.

Détails

ID Serval
serval:BIB_94E6C056BEAC
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Asymmetrical pre-synaptic and post-synpatic changes in the striatal dopamine projection in dopa naïve parkinsonism. Diagnostic implications of the D2 receptor status.
Périodique
Brain
Auteur(s)
Sawle G.V., Playford E.D., Brooks D.J., Quinn N., Frackowiak R.S.
ISSN
0006-8950 (Print)
ISSN-L
0006-8950
Statut éditorial
Publié
Date de publication
1993
Volume
116 ( Pt 4)
Pages
853-867
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Nine L-dopa na ve patients with clinically diagnosed parkinsonism were studied using positron emission tomography with 6-L-[18F]fluorodopa ([18F]dopa, a pre-synaptic tracer) and [11C]raclopride (which binds to D2 receptors). Putamen [18F]dopa uptake was reduced in all patients, confirming a loss of function affecting the nigrostriatal projection. In eight patients the putamen with the lowest [18F]dopa uptake (always contralateral to the clinically most affected side) had the highest [11C]raclopride binding, suggesting upregulation of the post-synaptic D2 receptors. In the ninth patient [11C]raclopride binding was lower in the putamen with the lowest [18F]dopa uptake, indicating an additional post-synaptic deficit. All nine patients were shown to be L-dopa responsive. The subsequent clinical course of the former eight patients has been typical of idiopathic Parkinson's disease, whilst the ninth patient has developed postural hypotension, urinary incontinence and respiratory stridor typical of multiple system atrophy. Reduced [11C]raclopride binding in L-dopa naïve parkinsonian patients might serve as a useful early marker of this condition.
Mots-clé
Adult, Aged, Carbon Radioisotopes/diagnostic use, Corpus Striatum/metabolism, Corpus Striatum/radionuclide imaging, Dihydroxyphenylalanine/analogs & derivatives, Dihydroxyphenylalanine/metabolism, Dopamine/metabolism, Female, Fluorine Radioisotopes/diagnostic use, Humans, Middle Aged, Parkinson Disease/complications, Parkinson Disease/metabolism, Raclopride, Receptors, Dopamine D2/metabolism, Salicylamides/diagnostic use, Salicylamides/metabolism, Synapses/metabolism, Synapses/pathology, Tomography, Emission-Computed
Pubmed
Web of science
Création de la notice
22/09/2011 18:31
Dernière modification de la notice
20/08/2019 15:57
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