Limited heterogeneity of autoantigens and T cells in autoimmune diseases?

Détails

ID Serval
serval:BIB_94DEBA6EC840
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Limited heterogeneity of autoantigens and T cells in autoimmune diseases?
Périodique
Research in Immunology
Auteur(s)
Acha-Orbea H.
ISSN
0923-2494 (Print)
ISSN-L
0923-2494
Statut éditorial
Publié
Date de publication
1991
Volume
142
Numéro
5-6
Pages
487-490
Langue
anglais
Résumé
For many induced and spontaneous autoimmune diseases, a predominant role for T cells in the organ-specific destruction process has been shown. In one of the induced models of autoimmunity, experimental allergic encephalomyelitis (EAE), a very small heterogeneity of T-cell receptor (TcR) molecules is expressed by the pathogenic T cells in both rats and mice. Contrary to induced autoimmune diseases, little is known about the autoantigens recognized by these autoimmune T cells and the heterogeneity of their TcR in spontaneous autoimmune diseases. The aim of this work was to establish a system which allows characterization of relevant autoantigens in spontaneous insulin-dependent diabetes mellitus (IDDM) in non-obese diabetic (NOD) mice. A completely different approach was taken to characterize the gene products of the minor lymphocyte stimulatory (Mls) loci. These gene products are responsible for the clonal elimination or the clonal stimulation of T cells expressing particular TcR V beta genes and therefore could be implicated in induction of autoimmune diseases by oligoclonal T-cell populations. The finding that Mls antigens are encoded by retroviral sequences leads to the hypothesis that viruses could be the inducing agents of autoimmune diseases.
Mots-clé
Animals, Autoantigens/immunology, Autoimmune Diseases/immunology, Autoimmunity/immunology, Diabetes Mellitus, Type 1/immunology, Disease Models, Animal, Major Histocompatibility Complex/immunology, Mice, Mice, Inbred NOD, Receptors, Antigen, T-Cell/immunology, T-Lymphocytes/immunology
Pubmed
Web of science
Création de la notice
24/01/2008 15:48
Dernière modification de la notice
20/08/2019 15:57
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