Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics.

Détails

ID Serval
serval:BIB_94B9EA9825A4
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics.
Périodique
Nature protocols
Auteur⸱e⸱s
Capogrosso M., Wagner F.B., Gandar J., Moraud E.M., Wenger N., Milekovic T., Shkorbatova P., Pavlova N., Musienko P., Bezard E., Bloch J., Courtine G.
ISSN
1750-2799 (Electronic)
ISSN-L
1750-2799
Statut éditorial
Publié
Date de publication
09/2018
Peer-reviewed
Oui
Volume
13
Numéro
9
Pages
2031-2061
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders. Here, we describe equipment and surgical procedures that can be used to acquire chronic electromyographic (EMG) recordings from leg muscles and to implant targeted spinal cord stimulation systems that remain stable up to several months after implantation in rats and nonhuman primates. We also detail how to exploit these implants to configure electrical spinal cord stimulation policies that allow control over the degree of extension and flexion of each leg during locomotion. This protocol uses real-time processing of gait kinematics and locomotor performance, and can be configured within a few days. Once configured, stimulation bursts are delivered over specific spinal cord locations with precise timing that reproduces the natural spatiotemporal activation of motoneurons during locomotion. These protocols can also be easily adapted for the safe implantation of systems in the vicinity of the spinal cord and to conduct experiments involving real-time movement feedback and closed-loop controllers.
Pubmed
Web of science
Création de la notice
05/10/2018 16:51
Dernière modification de la notice
20/08/2019 14:57
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