Plasma taurine as a predictor of poor outcome in patients with mild neurological deficits after aneurysmal subarachnoid hemorrhage.

Détails

ID Serval
serval:BIB_9484AAE2E2F8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Plasma taurine as a predictor of poor outcome in patients with mild neurological deficits after aneurysmal subarachnoid hemorrhage.
Périodique
Journal of neurosurgery
Auteur(s)
Barges-Coll J., Pérez-Neri I., Avendaño J., Mendez-Rosito D., Gomez-Amador J.L., Ríos C.
ISSN
1933-0693 (Electronic)
ISSN-L
0022-3085
Statut éditorial
Publié
Date de publication
10/2013
Peer-reviewed
Oui
Volume
119
Numéro
4
Pages
1021-1027
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The object of this study was to determine the relationship between plasma taurine and subarachnoid hemorrhage (SAH) outcome.
Forty patients with SAH and mild neurological deficits were included in this prospective, blinded cohort study. Plasma taurine levels were measured using high-performance liquid chromatography on admission and were correlated with patient outcomes at discharge.
Twenty-five percent of the patients ultimately had a poor outcome. Plasma taurine concentrations at admission were increased (2-fold) in SAH patients with a favorable outcome and were further increased (6-fold) in those who had a poor outcome. Increased taurine levels identified patients who would be discharged with a poor outcome, with sensitivity and specificity values of approximately 80% and 100%, respectively, and positive and negative predictive values of approximately 90%. Delayed cerebral vasospasm showed an OR of 27.9 (95% CI 1.090-714.9) for a poor outcome, whereas an increased taurine concentration had an OR of 105 for a poor outcome (95% CI 8.3-1328.0, p < 0.001).
Increased plasma taurine concentrations on admission predict a poor outcome in SAH.
Mots-clé
Adult, Cerebral Angiography, Female, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Single-Blind Method, Subarachnoid Hemorrhage/blood, Subarachnoid Hemorrhage/diagnostic imaging, Subarachnoid Hemorrhage/therapy, Taurine/blood, Treatment Outcome
Pubmed
Web of science
Création de la notice
10/09/2019 17:48
Dernière modification de la notice
11/09/2019 6:26
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