Metabolic control in cancer cells.

Détails

ID Serval
serval:BIB_93D3D2F9CC0B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Metabolic control in cancer cells.
Périodique
Annales d'endocrinologie
Auteur(s)
Fajas L.
ISSN
0003-4266 (Print)
ISSN-L
0003-4266
Statut éditorial
Publié
Date de publication
2013
Volume
74
Numéro
2
Pages
71-73
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
An important hallmark of cancer cells is a profound change in metabolism. Indeed, most tumor cells are characterized by higher rates of glycolysis, lactate production, and biosynthesis of lipids and other macromolecules. Our group, among others, has previously demonstrated a close relationship between metabolic responses and proliferative stimuli, showing that cell cycle regulators have a major role in the control of metabolism. Changes in this coordinated response might lead to abnormal metabolic changes during tumor development and cancer progression. In this paper we review the dual role of cell cycle regulators in the control of both proliferation and metabolism in normal and in cancer cells. We show participation of the E2F1-CDK4 axis in the modulation of oxidative metabolism, in the positive regulation of lipid synthesis, and the regulation glycolysis. These three metabolic pathways are, interestingly fundamental in providing synthetic processes, energy production and cell signaling events, which are crucial factors for cancer cell survival.
Pubmed
Web of science
Création de la notice
04/08/2013 9:34
Dernière modification de la notice
20/08/2019 15:56
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