The course of malaria in mice: major histocompatibility complex (MHC) effects, but no general MHC heterozygote advantage in single-strain infections.

Détails

ID Serval
serval:BIB_93A5DD69252C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The course of malaria in mice: major histocompatibility complex (MHC) effects, but no general MHC heterozygote advantage in single-strain infections.
Périodique
Genetics
Auteur⸱e⸱s
Wedekind C., Walker M., Little T.J.
ISSN
0016-6731[print], 0016-6731[linking]
Statut éditorial
Publié
Date de publication
07/2005
Peer-reviewed
Oui
Volume
170
Numéro
3
Pages
1427-1430
Langue
anglais
Résumé
A general MHC-heterozygote advantage in parasite-infected organisms is often assumed, although there is little experimental evidence for this. We tested the response of MHC-congenic mice (F2 segregants) to malaria and found the course of infection to be significantly influenced by MHC haplotype, parasite strain, and host gender. However, the MHC heterozygotes did worse than expected from the average response of the homozygotes.
Mots-clé
Animals, Blood Cell Count, Body Weight, Crosses, Genetic, Disease Progression, Haplotypes/genetics, Heterozygote, Host-Parasite Interactions, Major Histocompatibility Complex/genetics, Malaria/genetics, Malaria/physiopathology, Mice, Mice, Inbred Strains, Parasitemia/parasitology, Plasmodium chabaudi, Sex Factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 10:43
Dernière modification de la notice
20/08/2019 14:56
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