Severe, chronic anorexia and extensive leg ulcerations as presenting signs of primary Sjogren's syndrome

Détails

ID Serval
serval:BIB_930B74C0D02E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Severe, chronic anorexia and extensive leg ulcerations as presenting signs of primary Sjogren's syndrome
Périodique
Dermatology
Auteur⸱e⸱s
Guggisberg  D., Perrenoud  D., Frenk  E.
ISSN
1018-8665
Statut éditorial
Publié
Date de publication
1997
Peer-reviewed
Oui
Volume
195
Numéro
1
Pages
93-5
Notes
Case Reports
Journal Article
Résumé
We report the case of a 75-year-old woman with a 15-year history of inappetance resulting in weight loss of approximately 40 kg. On physical examination, the skin of the lower extremities was markedly hyperpigmented with a brown-greyish hue. In addition, the skin of the legs was infiltrated, erythematous, riddled with erosions and necrotic ulcers. Clinical and laboratory evaluation revealed sicca syndrome, a pronounced polyclonal hypergammaglobulinemia (60 g/l), high levels of antinuclear, anti-SSA and anti-SSB antibodies. Histological examination of involved skin demonstrated a leukocytoclastic vasculitis.
Mots-clé
Adenosine Triphosphatases/immunology Aged Anorexia/diagnosis/*pathology Autoantibodies/analysis Autoantigens/analysis Chronic Disease Erythema/pathology Female Humans Hypergammaglobulinemia/pathology Hyperpigmentation/pathology Leg Ulcer/*pathology Necrosis *RNA, Small Cytoplasmic Ribonucleoproteins/analysis Sjogren's Syndrome/diagnosis/*pathology Vasculitis, Hypersensitivity/pathology Weight Loss
Pubmed
Web of science
Création de la notice
15/02/2008 14:07
Dernière modification de la notice
20/08/2019 15:55
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