Severe, chronic anorexia and extensive leg ulcerations as presenting signs of primary Sjogren's syndrome
Détails
ID Serval
serval:BIB_930B74C0D02E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Severe, chronic anorexia and extensive leg ulcerations as presenting signs of primary Sjogren's syndrome
Périodique
Dermatology
ISSN
1018-8665
Statut éditorial
Publié
Date de publication
1997
Peer-reviewed
Oui
Volume
195
Numéro
1
Pages
93-5
Notes
Case Reports
Journal Article
Journal Article
Résumé
We report the case of a 75-year-old woman with a 15-year history of inappetance resulting in weight loss of approximately 40 kg. On physical examination, the skin of the lower extremities was markedly hyperpigmented with a brown-greyish hue. In addition, the skin of the legs was infiltrated, erythematous, riddled with erosions and necrotic ulcers. Clinical and laboratory evaluation revealed sicca syndrome, a pronounced polyclonal hypergammaglobulinemia (60 g/l), high levels of antinuclear, anti-SSA and anti-SSB antibodies. Histological examination of involved skin demonstrated a leukocytoclastic vasculitis.
Mots-clé
Adenosine Triphosphatases/immunology
Aged
Anorexia/diagnosis/*pathology
Autoantibodies/analysis
Autoantigens/analysis
Chronic Disease
Erythema/pathology
Female
Humans
Hypergammaglobulinemia/pathology
Hyperpigmentation/pathology
Leg Ulcer/*pathology
Necrosis
*RNA, Small Cytoplasmic
Ribonucleoproteins/analysis
Sjogren's Syndrome/diagnosis/*pathology
Vasculitis, Hypersensitivity/pathology
Weight Loss
Pubmed
Web of science
Création de la notice
15/02/2008 14:07
Dernière modification de la notice
20/08/2019 15:55