Erste Resultate der HOT-Studie in der Schweiz. [Initial results of the HOT-study in Switzerland (hypertension optimal treatment)]

Détails

ID Serval
serval:BIB_92F7AA24EF0A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Erste Resultate der HOT-Studie in der Schweiz. [Initial results of the HOT-study in Switzerland (hypertension optimal treatment)]
Périodique
Praxis
Auteur(s)
Waeber B., Roth D.
ISSN
1661-8157
Statut éditorial
Publié
Date de publication
1995
Volume
84
Numéro
48
Pages
1432-1434
Langue
allemand
Résumé
The HOT study (hypertension-optimal treatment) is an international clinical study on primary prevention of cardiovascular events in 19,193 hypertensive patients worldwide. It aims at the recognition of the optimal diastolic blood pressure value (< 90, < 85 or < 80 mmHg?) in order to maximize the possible benefit of an antihypertensive therapy. In addition, the HOT study investigates whether low doses of aspirin (75 mg/day) are able to reduce the occurrence of severe cardiovascular events. In Switzerland a total of 797 patients have been enrolled in the study. Antihypertensive therapy was initiated with felodipine = Plendil (5 mg/day). This vasoelective calcium antagonist could reduce diastolic blood pressure values to < 90 or < 80 mg/Hg, respectively, in one of two or one of three patients within the first three months. In nine or six patients, respectively out of ten a reduction of diastolic blood pressure values to < 90 or < 80 mmHg was reached within one year by combination of felodipine with other antihypertensive drugs (ACE inhibitors, beta blockers and diuretics).
Mots-clé
Adrenergic beta-Antagonists/administration & dosageAgedAged, 80 and overAngiotensin-Converting Enzyme Inhibitors/administration & dosageAntihypertensive Agents/administration & dosage/*therapeutic useDouble-Blind MethodDrug Administration ScheduleDrug Therapy, CombinationFelodipine/administration & dosageFemaleHumansHypertension/*drug therapyMaleMiddle AgedProspective Studies
Pubmed
Création de la notice
04/03/2009 16:04
Dernière modification de la notice
20/08/2019 15:55
Données d'usage