Immunosenescence: Implications for vaccination programmes in adults.

Détails

ID Serval
serval:BIB_92EC40091B2A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Immunosenescence: Implications for vaccination programmes in adults.
Périodique
Maturitas
Auteur⸱e⸱s
Lang P.O., Govind S., Michel J.P., Aspinall R., Mitchell W.A.
ISSN
1873-4111 (Electronic)
ISSN-L
0378-5122
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
68
Numéro
4
Pages
322-330
Langue
anglais
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Résumé
Vaccination is crucially important in preventing infection and protecting vulnerable population from infectious diseases. However, a multitude of changes in the immune system occurring with advancing age, termed immunosenescence, lead to limit the protective effects of vaccination in older adults. While it is widely believed that the current immunization strategies saves many lives, vaccine preventable infectious diseases (VPDs) still place a considerable burden, not only on older individuals, but also on the adult population and healthcare systems of developed countries. This review will first examine the evidence linking the contribution of immunosenescence to a less than optimal vaccine response in aged individuals in order to demonstrate that strategy of promoting vaccination in these populations is not sufficient to reduce the burden associated with VPDs. Furthermore, based upon the side effects of the herd immunity when vaccine-policies are mainly childhood-centered, considerations will be given on the imperative necessity to frame shift our thinking and efforts away from a nearly complete childhood-centered vaccine programme toward a life-span immunization programmes.
Mots-clé
Aging/physiology, Communicable Disease Control/methods, Humans, Immunity/physiology, Immunity, Herd, Immunization Programs, Patient Selection, Vaccines/immunology
Pubmed
Web of science
Création de la notice
15/04/2015 9:30
Dernière modification de la notice
20/08/2019 14:55
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