mRNPs, polysomes or granules: FMRP in neuronal protein synthesis.

Détails

ID Serval
serval:BIB_92E44937DD0A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
mRNPs, polysomes or granules: FMRP in neuronal protein synthesis.
Périodique
Current opinion in neurobiology
Auteur⸱e⸱s
Zalfa F., Achsel T., Bagni C.
ISSN
0959-4388 (Print)
ISSN-L
0959-4388
Statut éditorial
Publié
Date de publication
06/2006
Volume
16
Numéro
3
Pages
265-269
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
mRNA localization and regulated translation play central roles in neurite outgrowth and synaptic plasticity. A key molecule in these processes is the Fragile X mental retardation protein, FMRP, which is involved in the metabolism of neuronal mRNAs. Absence or mutation of FMRP leads to spine dysmorphogenesis and impairs synaptic plasticity. Studies that have mainly been performed on the mouse and Drosophila models for Fragile X Syndrome showed that FMRP is involved in translational regulation at synapses, but even 15 years after discovery of the FMR1 gene, the precise working mechanisms remain elusive.

Mots-clé
Animals, Brain/growth & development, Brain/metabolism, Cytoplasmic Granules/genetics, Cytoplasmic Granules/metabolism, Dendritic Spines/metabolism, Dendritic Spines/pathology, Fragile X Mental Retardation Protein/genetics, Fragile X Mental Retardation Protein/metabolism, Humans, Nerve Tissue Proteins/biosynthesis, Nerve Tissue Proteins/genetics, Neuronal Plasticity/physiology, Neurons/metabolism, Polyribosomes/genetics, Polyribosomes/metabolism, Protein Biosynthesis/physiology, Ribonucleoproteins/genetics, Ribonucleoproteins/metabolism
Pubmed
Création de la notice
06/03/2017 17:23
Dernière modification de la notice
20/08/2019 14:55
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