Less is more: Antibiotics at the beginning of life.
Détails
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_92DFD80B4C7A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Less is more: Antibiotics at the beginning of life.
Périodique
Nature communications
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
27/04/2023
Peer-reviewed
Oui
Volume
14
Numéro
1
Pages
2423
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Publication Status: epublish
Résumé
Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance and perturbations of the developing microbiome. Early-life microbiome disruption increases the risks of developing chronic diseases later in life. Fear of missing evolving neonatal sepsis is the key driver for antibiotic overtreatment early in life. Bias (a systemic deviation towards overtreatment) and noise (a random scatter) affect the decision-making process. In this perspective, we advocate for a factual approach quantifying the burden of treatment in relation to the burden of disease balancing antimicrobial stewardship and effective sepsis management.
Mots-clé
Infant, Newborn, Humans, Anti-Bacterial Agents/pharmacology, Anti-Bacterial Agents/therapeutic use, Beginning of Human Life, Sepsis/drug therapy, Neonatal Sepsis/drug therapy, Antimicrobial Stewardship
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/05/2023 15:57
Dernière modification de la notice
23/01/2024 8:30