Perinatal and early postnatal changes in the expression of monocarboxylate transporters MCT1 and MCT2 in the rat forebrain

Détails

ID Serval
serval:BIB_92DAECF79055
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Perinatal and early postnatal changes in the expression of monocarboxylate transporters MCT1 and MCT2 in the rat forebrain
Périodique
Journal of Comparative Neurology
Auteur⸱e⸱s
Baud  O., Fayol  L., Gressens  P., Pellerin  L., Magistretti  P., Evrard  P., Verney  C.
ISSN
0021-9967 (Print)
Statut éditorial
Publié
Date de publication
10/2003
Volume
465
Numéro
3
Pages
445-54
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct 20
Résumé
In addition to glucose, monocarboxylates including lactate represent a major source of energy for the brain, especially during development. We studied the immunocytochemical expression of the monocarboxylate transporters MCT1 and MCT2 in the rat brain between embryonic day (E) 16 and postnatal day (P) 14. At E16-18, MCT1-like immunoreactivity was found throughout the cortical anlage, being particularly marked medially in the hippocampal anlage next to the ventricle. In a complementary pattern, MCT2-like immunoreactivity was expressed along the medial and ventral border of the ventricle in the medial septum and habenula before birth. The hypothalamic area exhibited MCT2 and MCT1 positive areas from E18 on. These transient labelings revealed four main sites of monocarboxylate and/or glucose exchange: the brain parenchyma, the epithelial cells, the ependymocytes, and the glia limitans. During the first postnatal week, MCT1 immunoreactivity extended massively to the vessel walls and moderately to the developing astrocytes in the cortex. In contrast, MCT2 immunoreactivity was faint in blood vessels but massive in developing astrocytes from P3 to P7. Neither MCT2 nor MCT1 colocalized with neuronal, microglial, or oligodendrocytic markers during the first postnatal week. At P14, a part of the scattered punctate MCT2 staining could be associated with astrocytes and postsynaptic dendritic labeling. The transient pattern of expression of MCTs throughout the perinatal period suggests a potential relationship with the maturation of the blood-brain barrier.
Mots-clé
Animals Animals, Newborn Embryo/embryology/metabolism Gene Expression Regulation, Developmental/*physiology Monocarboxylic Acid Transporters/*biosynthesis/genetics Prosencephalon/embryology/*growth & development/*metabolism Rats Symporters/*biosynthesis/genetics
Pubmed
Web of science
Création de la notice
24/01/2008 13:17
Dernière modification de la notice
20/08/2019 14:55
Données d'usage