Regulation of lymphocyte proliferation and death by FLIP.

Détails

ID Serval
serval:BIB_92D5671A9800
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Regulation of lymphocyte proliferation and death by FLIP.
Périodique
Nature Reviews. Immunology
Auteur(s)
Thome M., Tschopp J.
ISSN
1474-1733[print], 1474-1733[linking]
Statut éditorial
Publié
Date de publication
2001
Volume
1
Numéro
1
Pages
50-58
Langue
anglais
Résumé
Lymphocyte homeostasis is a balance between lymphocyte proliferation and lymphocyte death. Tight control of apoptosis is essential for immune function, because its altered regulation can result in cancer and autoimmunity. Signals from members of the tumour-necrosis-factor receptor (TNF-R) family, such as Fas and TNF-R1, activate the caspase cascade and result in lymphocyte death by apoptosis. Anti-apoptotic proteins, such as FLIP (also known as FLICE/caspase-8 inhibitory protein) have recently been identified. FLIP expression is tightly regulated in T cells and might be involved in the control of both T-cell activation and death. Abnormal expression of FLIP might have a role not only in autoimmune diseases, but also in tumour development and cardiovascular disorders.
Mots-clé
Animals, Antigens, CD95/immunology, Apoptosis, Autoimmune Diseases/immunology, CASP8 and FADD-Like Apoptosis Regulating Protein, Carrier Proteins/chemistry, Carrier Proteins/genetics, Cell Division, Humans, Intracellular Signaling Peptides and Proteins, Leukocytes/cytology, Leukocytes/immunology, Lymphocyte Activation, Lymphocytes/cytology, Lymphocytes/immunology, Models, Immunological, Signal Transduction
Pubmed
Web of science
Création de la notice
24/01/2008 16:18
Dernière modification de la notice
20/08/2019 15:55
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