Aldosterone effects on glomerular structure and function.

Détails

ID Serval
serval:BIB_92321B5293C2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Aldosterone effects on glomerular structure and function.
Périodique
Journal of the Renin-angiotensin-aldosterone System : Jraas
Auteur⸱e⸱s
Bernardi S., Toffoli B., Zennaro C., Bossi F., Losurdo P., Michelli A., Carretta R., Mulatero P., Fallo F., Veglio F., Fabris B.
ISSN
1752-8976 (Electronic)
ISSN-L
1470-3203
Statut éditorial
Publié
Date de publication
2015
Volume
16
Numéro
4
Pages
730-738
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
OBJECTIVE: Experimental evidence suggests that aldosterone directly contributes to organ damage by promoting cell growth, fibrosis, and inflammation. Based on these premises, this work aimed to assess the glomerular effects of aldosterone, alone and in combination with salt.
METHODS: After undergoing uninephrectomy, 75 rats were allocated to five groups: control, salt diet, aldosterone, aldosterone + salt diet, aldosterone + salt diet and eplerenone, and they were all studied for four weeks. We focused on glomerular structural, functional, and molecular changes, including slit diaphragm components, local renin-angiotensin system activation, as well as pro-oxidative and profibrotic changes.
RESULTS: Aldosterone significantly increased systolic blood pressure, led to glomerular hypertrophy, mesangial expansion, and it significantly increased the glomerular permeability to albumin and the albumin excretion rate, indicating the presence of glomerular damage. These effects were worsened by adding salt to aldosterone, while they were reduced by eplerenone. Aldosterone-induced glomerular damage was associated with glomerular angiotensin-converting enzyme (ACE) 2 downregulation, with ACE/ACE2 ratio increase, ANP decrease, as well as with glomerular pro-oxidative and profibrotic changes.
CONCLUSIONS: Aldosterone damages not only the structure but also the function of the glomerulus. ACE/ACE2 upregulation, ACE2 and ANP downregulation, and pro-oxidative and profibrotic changes are possible mechanisms accounting for aldosterone-induced glomerular injury.
Mots-clé
Aldosterone/pharmacology, Animals, Fibrosis, Glomerular Filtration Rate/drug effects, Kidney Glomerulus/drug effects, Kidney Glomerulus/pathology, Male, Oxidation-Reduction/drug effects, Oxidative Stress/drug effects, Rats, Wistar, Renin-Angiotensin System/drug effects, Sodium Chloride, Dietary/pharmacology
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2016 15:01
Dernière modification de la notice
20/08/2019 14:55
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