PPARs: nuclear receptors for fatty acids, eicosanoids, and xenobiotics.

Détails

ID Serval
serval:BIB_921F2725A575
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
PPARs: nuclear receptors for fatty acids, eicosanoids, and xenobiotics.
Périodique
Advances in Experimental Medicine and Biology
Auteur⸱e⸱s
Devchand P.R., Ijpenberg A., Devesvergne B., Wahli W.
ISSN
0065-2598[print], 0065-2598[linking]
Statut éditorial
Publié
Date de publication
1999
Volume
469
Pages
231-236
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The peroxisome proliferator-activated receptors have enjoyed the spotlight for many reasons. These transcription factors are ligand-inducible nuclear receptors that modulate gene expression in response to a broad spectrum of compounds. The recognition that PPARs are indeed nuclear receptors for polyunsaturated fatty acids, some eicosanoids and also lipid-lowering and antidiabetic drugs, has opened many exciting avenues of research and drug discovery. Recent studies on the PPAR function have extended the role of these transcription factors beyond energy homeostasis to master gene in adipogenesis and also determinants in inflammation control. While rapid advances have been made, it is clear that we are far from a global understanding of the mechanisms and functions of PPARs.
Mots-clé
Animals, Binding Sites/genetics, Biological Assay/methods, DNA/genetics, DNA/metabolism, Dimerization, Eicosanoids/metabolism, Fatty Acids/metabolism, Histone Acetyltransferases, Ligands, Mammals, Nuclear Receptor Coactivator 1, Peroxisomes/metabolism, Receptors, Cytoplasmic and Nuclear/chemistry, Receptors, Cytoplasmic and Nuclear/metabolism, Receptors, Retinoic Acid/chemistry, Receptors, Retinoic Acid/metabolism, Retinoid X Receptors, Transcription Factors/chemistry, Transcription Factors/metabolism, Xenobiotics/metabolism, Xenopus
Pubmed
Web of science
Création de la notice
24/01/2008 16:04
Dernière modification de la notice
20/08/2019 14:55
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